Cardiovascular Reactivity after Bilateral Nephrectomy in Rats
スポンサーリンク
概要
- 論文の詳細を見る
(1) Cardiovascular reactivity, 16 to 28 hours after bilateral nephrectomy was determined in rats by obtaining the dose-blood pressure-response curve in order to avoid the vertical bias.(2) Bilateral nephrectomy did not increase cardiovascular reactivity to pressor agents (angiotensin and norepinephrine) in rats anesthetized by pentobarbital or anesthetized and treated by pentolinium, a ganglion blocking agent.(3) In pithed animals without anesthesia nephrectomy augmented slightly but definitely the response to pressor agents.(4) Further elimination of the neural innervation in pithed animals by administration of bretylium, an adrenergic neurone blocking agent, atropine, and pentolinium, also resulted in an increased response to angiotensin after bilateral nephrectomy.(5) But it is inadequate to explain the marked augmentation of response to renin after nephrectomy only by the slight increase in response to angiotensin. Response to renin was markedly augmented in pithed animals as well as under usual condition.(6) Bilateral nephrectomy diminished cardiovascular reactivity to depressor agents (acetylcholine, adenosine triphosphate and histamine).(7) Angiotensinogen in the plasma increased 4 times more after bilateral nephrectomy. This is the main cause of marked augmentation in response to renin.(8) The claim that, if angiotensinogen is already in excess, a further increase in its concentration would not lead to an increased production of angiotensin was denied experimentally and theoretically.
- International Heart Journal刊行会の論文
著者
-
Sakai Fuminori
Department Of Pharmacology Faculty Of Medicine University Of Tokyo
-
Mizogami Susumu
Department Of Pharmacology Toho University School Of Medicine:(presuent Address)research Laboratory
-
SOKABE Hirofumi
Departine rt of Pharmacology, Jichi Medical School
-
SHIBAYAMA Fumio
Department of Pharmacology, Faculty of Medicine, University of Tokyo
関連論文
- RELATIONSHIP BETWEEN γ-GLUTAMYL TRANSPEPTIDASE ACTIVITY IN URINE AND RENAL PROXIMAL TUBULAR DAMAGE(S) BY NEPHROTOXIC AGENTS (The 6th Meeting for the Study of Toxic Effect)
- SUPPRESSIVE EFFECT OF DIPYRIDAMOLE ON THE PROTEINURIA OF AMINONUCLEOSIDE NEPHROSIS IN RAT.
- EFFECTS OF MERCURY ON THE STRUCTURAL GLYCOPROTEINS OF VARIOUS SEGMENTS IN ISOLATED NEPHRON (The 5th Meeting for the Study of Toxic Effect)
- EFFECTS OF MERCURY ON THE STRUCTURAL PROTEINS OF VARIOUS SEGMENTS IN ISOLATED NEPHRON (The Fourth Meeting for the Study of Toxic Effect)
- 215. TOXIC ACTION OF HEAVY METALS. 2. ANALYSIS OF PROTEINURIA DUE TO MERCURY (The Third Meeting for the Study of Toxic Effect)
- 103. EFFECT OF MERCURY ON THE NEWT KIDNEY (The Second Meeting for the Study of Toxic Effect)
- NARCOTIC PHYSICAL DEPENDENCE AND URINARY SEX-DEPENDENT LOW MOLECULAR WEIGHT PROTEINS IN MALE RATS
- ACUTE AND SUBCHRONIC EFFECTS OF BOMETOLOL ON BLOOD PRESSURE IN HYPERTENSIVE RATS
- A NEW APPROACH FOR ASSESSMENT OF NARCOTIC PHYSICAL DEPENDENCE USING URINARY SEX-DEPENDENT LOW MOLECULAR WEIGHT PROTEINS IN MALE RATS
- DISTRIBUTION OF GAMMA-GLUTAMYL TRANSPEPTIDASE AND GLUTAMINASE ISOENZYMES IN THE RABBIT SINGLE NEPHRON
- MICROPUNCTURE STUDY OF PROTEIN CONCENTRATION IN GLOMERULAR FLUID IN THE NEWT
- Partial Purification of a Transcellular-Fluid-Forming Factor from the Renal Cortex
- Increase in Vascular Sensitivity to Angiotensin II and Norepinephrine after Four - Day Infusion of 0.3M Sodium Chloride in Conscious Kininogen - Deficient Brown Norway Katholiek Rats
- Plasma Renin Activity Determined by Two Different Methods in Spontaneously Hypertensive Rats
- CHRONIC EFFECTS OF BUNITROLOL AND PINDOLOL ON BLOOD PRESSURE, HEART RATE, VASCULAR LESIONS, AND PLASMA RENIN ACTIVITY IN HYPERTENSIVE RATS
- Some Frontiers in Comparative Studies of the Renin-Angiotensin System
- EFFECTS OF FASTING ON THE HENLES LOOP FUNCTION OF RAT KIDNEY
- EFFECTS OF ALDOSTERONE AND CORTISOL ON HENLES LOOP IN THE ADRENALECTOMIZED RATS KIDNEY
- POSTNATAL DEVELOPMENT OF UREA CONCENTRATION IN THE NEWBORN RABBITS KIDNEY
- A NEW ULTRAMICRO ANALYSIS OF PROTEIN BY S.D.S.1 POLYACRYLAMIDE GEL ELECTROPHORESIS
- A SIMPLE METHOD TO DETERMINE THE RATIO OF CARDIAC TO VASCULAR β-RECEPTOR BLOCKADE IN THE RAT IN VIVO
- THE TRANSCELLULAR FLUID FORMING FACTOR AND RENIN IN THE KIDNEY OF HYPERTENSIVE OR SALT-LOADED RATS
- EFFECTS OF LONG-TERM TREATMENTS WITH CAPTOPRIL ON BLOOD PRESSURE AND RENIN ACTIVITY IN THE STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS
- ANTIHYPERTENSIVE AND ANTIDIURETIC EFFECTS OF 3-HYDRAZINO-6-[N, N-BIS (2-HYDROXYETHYL) AMINO]-PYRIDAZINE (L 6150) IN RATS
- EFFECTS OF β-ADRENERGIC BLOCKING DRUGS IN HYPERTENSIVE RATS
- ACUTE VASODEPRESSOR EFFECT OF D-3-MERCAPTO-2-METHYLPROPANOYL-L-PROLINE (SQ 14, 225) IN THE STROKE-PRONE SUBSTRAIN OF SPONTANEOUSLY HYPERTENSIVE RATS (SHRSP)
- SPECIFIC PRESSOR ACTIVITY OF ANGIOTENSINS I AND II
- EFFECTS OF STARVATION ON MICROSOMAL CYTOCHROME P-450 AND LAURATE-ω-HYDROXYLATION OF RAT KIDNEY AND LIVER
- CYCLIC AMP-DEPENDENT PROTEIN KINASE ACTIVITY AND ENDOGENOUS PROTEIN PHOSPHORYLATION IN ISOLATED CORTICAL SEGMENTS OF RABBIT NEPHRON
- Sympathetic Nervous Activity in Renal and DOC Hypertensive Rats
- TRANSCELLULAR FLUID FORMATION AND VASCULAR PERMEABILATIY INCREASE BY ANGIOTENSINS
- A METHOD FOR EXPOSURE OF GLOMERULI AND DEEP TUBULAR SEGMENTS IN RENAL CORTEX OF THE RAT
- Inhibition of Angiotensinases in the Rat Plasma and Kidney
- DIFFERENCE IN HYPOTENSIVE RESPONSE TO L-DOPA AND A DECARBOXYLASE INHIBITOR IN VARIOUS FORMS OF HYPERTENSIVE RATS
- Reactivity of Norepinephrine Receptors in the Cardiovascular System of Hypertensive Rats
- SPECIFIC PRESSOR ACTIVITY AND STABILITY OF SYNTHETIC ANGIOTENSINS
- The Spontaneously Hypertensive Rat (8) : Proceedings of VIII Annual Scientific Meeting of the Council for the Spontaneously Hypertensive Rat October 8, 1972, Nagasaki
- Interpretation by the Deficiency Theory
- SPONTANEOUS PERIODIC CHANGE IN ELECTROENCEPHALOGRAM
- Cardiovascular Reactivity in Hypertensive Rats
- Effects of FR50948, a new orally active antiallergic agent, in experimental allergic models.
- Effect of 3-hydrazino-6-[N, N-bis (2-hydroxyethyl) amino]-pyridazine (L 6150) on renin in hypertensive rats.
- Plasma Renin Activity in the Spontaneously Hypertensive Rat of Early Hypertensive Stage
- CENTRAL EFFECTS OF PHENCYCLIDINE HYDROCHLORIDE (SERNYL)
- Effects of enalapril and captopril on urinary excretion of kinins and electrolytes in stroke-prone spontaneously hypertensive rats.
- Effects of Antihypertensive Treatments on Ocular Lesions of Streptozotocin-Induced Diabetes Mellitus in Spontaneously Hypertensive Rats
- Renal Lesions of Streptozotocin-Induced Diabetes Mellitus in Spontaneously Hypertensive Rats
- Determination of Renin in Rat and Human Kidneys
- PYROGEN-PRODUCING MOLDS AND OTHER MICROBES EXISTING IN GLUCOSE-POWDER
- Chronic effects of enalapril on blood pressure, stroke, plasma renin, urinary electrolytes and PGE2 excretion in stroke-prone spontaneously hypertensive rats.
- Plasma Renin Activity and Excretion of Water and Electrolytes in Stroke-prone SHR Rats
- Cardiovascular Reactivity after Bilateral Nephrectomy in Rats
- Plasma Renin Activity in SHR
- THE ROLE OF PYROGENS IN GLUCOSE SOLUTION AS A CAUSE OF PYREXIA
- Acute Hypotensive Action of Parathyroid Hormone-(1-34) Fragments in Hypertensive Rats
- Evaluation of the New Rat Tail Blood Pressure Determining System
- Prewarming Condition for Determining the Tail Blood Pressure in Rats
- Further Studies on the Determination of Renin in Rat Kidney
- Pharmacodynamic and pharmacokinetic studies on prizidilol and nipradilol (K-351), antihypertensive drugs with combined vasodilator and .BETA.-adrenoceptor blocking actions, in rabbits.