Inhibition of Angiotensinases in the Rat Plasma and Kidney
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概要
- 論文の詳細を見る
The plasma and kidney angiotensinases were compared in the rat. Effects of acid and alkali treatments and of enzyme inhibitors on the angiotensinase activities and the renin-angiotensionogen reaction were studied. Angiotensinase activity of the plasma was greatest near neutral pH at 37°C and was blocked almost completely by dialysis against disodium ethylenediaminetetraacetic acid (EDTA). The kidney angiotensinase at neutral pH was also inactivated by acidification and dialysis against EDTA. The activity having a optimum pH of 4.5 to 5.0 was not affected by the dialysis but was inhibited by alkali or diisopropyl fluorophosphate. The renin-angiotensinogen reaction was least affected by incubation of the acid-treated and dialysed kidney extract with the dialysed plasma at pH 7.4 and 37°C.
- International Heart Journal刊行会の論文
著者
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Sokabe Hirofumi
Department Of Parmacology Toho University Shool Of Medicine
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Nishimura Hiroko
Department Of Physiology University Of Tennessee
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SOKABE Hirofumi
Departine rt of Pharmacology, Jichi Medical School
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NISHIMURA Hiroko
Department of Pharmacology, Toho University School of Medicine
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