SPECIFIC PRESSOR ACTIVITY AND STABILITY OF SYNTHETIC ANGIOTENSINS

スポンサーリンク

概要

• 論文の詳細を見る

• Specific pressor activity of Asp<SUP>1</SUP>-Val<SUP>5</SUP>-angiotensins I and II was determined by a 4-point assay in rats against various synthetic angiotensins. Specific pressor activity of various angiotensins was also obtained from the dose-blood pressure-response (DR) curve, using a single angiotensin sample per rat. Comparison of two values showed that two angiotensins interacted in the 4-point assay, yielding a potentiation factor of 0.465-1.373. Therefore, specific pressor activity from DR curve is more reliable, because two angiotensins are not able to interact. Potency ratio on a molar basis of Asp<SUP>1</SUP>-IIe<SUP>5</SUP>-angiotensin I, Asp<SUP>1</SUP>-Val<SUP>5</SUP>-angiotensins I and II, Asn<SUP>1</SUP>-Val<SUP>5</SUP>-angiotensin II(Ciba Lot-094691), and Asp<SUP>1</SUP>-Va1<SUP>5</SUP>-Ser<SUP>9</SUP>-angiotensin I against Asp<SUP>1</SUP>-IIe<SUP>5</SUP>-angiotensin II were 0.76, 0.91, 2.02, 0.50, and 1.39, respectively. Asp<SUP>1</SUP>-Va1<SUP>5</SUP>-angiotensin II had twice the pressor activity of Asp<SUP>1</SUP>-IIe<SUP>5</SUP>-angiotensin II. Lyophylized Asp<SUP>1</SUP>-IIe<SUP>5</SUP>-angio-tensins I and II kept desiccated at minus;20°C, were stable for 27 months. Solutions of 100, 10, and 0.8 μg/ml were stable for 12, 8, and 6 months at minus;20°C, respectively.

• 社団法人 日本薬理学会の論文

著者

• Sakakibara Shumpei

  Peptide Institute Inc. Protein Research Foundation

• Sokabe Hirofumi

  Department Of Parmacology Toho University Shool Of Medicine

• Watanabe Takushi

  Department Of Pharmacology Jichi Medical School

• Nakajima Terumi

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• HONDA Ichiro

  Peptide Institute, Protein Research Foundation

• NAKAYAMA Taeko

  Institutes of Pharmaceutical Sciences, Hiroshima University School of Medicine

• SOKABE Hirofumi

  Departine rt of Pharmacology, Jichi Medical School

• Sakakibara Shumpei

  Peptide Center, Institute for Protein Research, Osaka University

• Honda Ichiro

  Peptide Center, Institute for Protein Research, Osaka University

関連論文

• THE REACTION BETWEEN HISTIDINE-CONTAINING PEPTIDE AND BIOLOGICALLY ESSENTIAL METAL ION : PROTONATION AND THE COMPLEXING ABILITY OF IMIDAZOLE RING
• Molecular Mechanism of Action by Atrial Natriuretic Peptide in Rat Vascular Smooth Muscle Cells : SYMPOSIUM ON ATRIAL NATRIURETIC POLYPEPTIDE (ANP): Basic and Clinical Research : 51th Annual Scientific Session of the Japanese Circulation Society
• Enzyme-Linked Immunoassay for Midkine, and Its Application to Evaluation of Midkine Levels in Developing Mouse Brain and Sera from Patients with Hepatocellular Carcinomas
• Total Synthesis of Aequorea Green Fluorescent Protein
• Chemical Synthesis of Dendrotoxin I : Revision of the Reported Structure
• Solution Synthesis of Calcicludine (CaC) : A Potent Blocker of an L-subtype of Neuronal Ca^ Channels
• Smooth Muscle Relaxing and Hypotensive Activities of Synthetic Calciseptine and the Homologous Snake Venom Peptide FS_2
• Amino Acid Sequence of Sardine Calcitonin and Its Hypocalcemic Activity in Rats
• Solution Structure of α-Conotoxin SI Determined by Two-Dimensional NMR Spectroscopy
• ACUTE AND SUBCHRONIC EFFECTS OF BOMETOLOL ON BLOOD PRESSURE IN HYPERTENSIVE RATS
• Vasodepressor Effect of Atrial Natriuretic Peptides in the Quail, Coturnix coturnix japonica : Endocrinology
• INTERACTION OF WASP VENOM PEPTIDE, MASTOPARAN, WITH PHOSPHOLIPID MEMBRANE; : BIOLOGICAL ACTIVITY AND DYNAMIC STRUCTURE OF MEMBRANE-BOUND STATE
• Comparative Biochemistry of Renins and Angiotensins in the Vertebrates
• Partial Purification of a Transcellular-Fluid-Forming Factor from the Renal Cortex
• Plasma Renin Activity Determined by Two Different Methods in Spontaneously Hypertensive Rats
• High Performance Liquid Chromatography of Bradykinin and Its Application to the Degradation Study of Bradykinin in Plasma (生体成分の高速液体クロマトグラフィ-)
• CHRONIC EFFECTS OF BUNITROLOL AND PINDOLOL ON BLOOD PRESSURE, HEART RATE, VASCULAR LESIONS, AND PLASMA RENIN ACTIVITY IN HYPERTENSIVE RATS
• Some Frontiers in Comparative Studies of the Renin-Angiotensin System
• CHRONIC EFFECTS OF A β-ADRENOCEPTOR BLOCKING DRUG, 4-[3-(tert-BUTYLAMINO)-2-HYDROXYPROPOXY]-N-METHYLISOCARBOSTYRIL HYDROCHLORIDE (N-696), IN HYPERTENSIVE RATS
• CHRONIC EFFECTS OF AROTINOLOL (S-596) IN SPONTANEOUSLY HYPERTENSIVE RATS
• EFFECTS OF ACUTE AND CHRONIC TREATMENTS WITH ATENOLOL AND PROPRANOLOL ON CARDIOVASCULAR RESPONSES TO HANDLING STRESS IN SPONTANEOUSLY HYPERTENSIVE RATS
• Application of N^-Cyclohexyloxycarbonyltryptophan to Peptide Synthesis
• Toward the Total Synthesis of Proteins
• A SIMPLE METHOD TO DETERMINE THE RATIO OF CARDIAC TO VASCULAR β-RECEPTOR BLOCKADE IN THE RAT IN VIVO
• COMBINED EFFECTS OF PHENOXYBENZAMINE AND PROPRANOLOL IN HYPERTENSIVE RATS
• THE TRANSCELLULAR FLUID FORMING FACTOR AND RENIN IN THE KIDNEY OF HYPERTENSIVE OR SALT-LOADED RATS
• EFFECTS OF LONG-TERM TREATMENTS WITH CAPTOPRIL ON BLOOD PRESSURE AND RENIN ACTIVITY IN THE STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS
• ANTIHYPERTENSIVE AND ANTIDIURETIC EFFECTS OF 3-HYDRAZINO-6-[N, N-BIS (2-HYDROXYETHYL) AMINO]-PYRIDAZINE (L 6150) IN RATS
• EFFECTS OF β-ADRENERGIC BLOCKING DRUGS IN HYPERTENSIVE RATS
• ACUTE VASODEPRESSOR EFFECT OF D-3-MERCAPTO-2-METHYLPROPANOYL-L-PROLINE (SQ 14, 225) IN THE STROKE-PRONE SUBSTRAIN OF SPONTANEOUSLY HYPERTENSIVE RATS (SHRSP)
• SPECIFIC PRESSOR ACTIVITY OF ANGIOTENSINS I AND II
• Sympathetic Nervous Activity in Renal and DOC Hypertensive Rats
• TRANSCELLULAR FLUID FORMATION AND VASCULAR PERMEABILATIY INCREASE BY ANGIOTENSINS
• Rathoimmunoassay of Human Calcitonin Using Labeled [Asu1, 7]-Human Calcitonin Analogue
• Inhibition of Angiotensinases in the Rat Plasma and Kidney
• Reactivity of Norepinephrine Receptors in the Cardiovascular System of Hypertensive Rats
• SPECIFIC PRESSOR ACTIVITY AND STABILITY OF SYNTHETIC ANGIOTENSINS
• THE RATIO OF CARDIAC TO VASCULAR β-RECEPTOR BLOCKADE OF ATENOLOL AND PROPRANOLOL IN SPONTANEOUSLY HYPERTENSIVE RATS IN VIVO
• The Spontaneously Hypertensive Rat (8) : Proceedings of VIII Annual Scientific Meeting of the Council for the Spontaneously Hypertensive Rat October 8, 1972, Nagasaki
• Interpretation by the Deficiency Theory
• Cardiovascular Reactivity in Hypertensive Rats
• Action of fragments of human parathyroid hormone on blood pressure in rats.
• Effect of 3-hydrazino-6-[N, N-bis (2-hydroxyethyl) amino]-pyridazine (L 6150) on renin in hypertensive rats.
• Plasma Renin Activity in the Spontaneously Hypertensive Rat of Early Hypertensive Stage
• Effects of Peptides on the Release of Catecholamines and Adenine Nucleotides from Cultured Adrenal Chromaffin Cells:Mastoparan-Induced Release
• Effects of enalapril and captopril on urinary excretion of kinins and electrolytes in stroke-prone spontaneously hypertensive rats.
• The presence of substance P carboxy-terminal heptapeptide in pig brain stem.
• Effects of Antihypertensive Treatments on Ocular Lesions of Streptozotocin-Induced Diabetes Mellitus in Spontaneously Hypertensive Rats
• Renal Lesions of Streptozotocin-Induced Diabetes Mellitus in Spontaneously Hypertensive Rats
• Determination of Renin in Rat and Human Kidneys
• Chronic effects of enalapril on blood pressure, stroke, plasma renin, urinary electrolytes and PGE2 excretion in stroke-prone spontaneously hypertensive rats.
• Plasma Renin Activity and Excretion of Water and Electrolytes in Stroke-prone SHR Rats
• Cardiovascular Reactivity after Bilateral Nephrectomy in Rats
• Plasma Renin Activity in SHR
• A New Protective Group Suitable for Masking Specific Amino Groups during Peptide Synthesis
• Studies on the Synthesis of Histidine Peptides. I. Nim-Tosylhistidine Derivatives as Starting Materials
• Acute Hypotensive Action of Parathyroid Hormone-(1-34) Fragments in Hypertensive Rats
• Evaluation of the New Rat Tail Blood Pressure Determining System
• Prewarming Condition for Determining the Tail Blood Pressure in Rats
• Further Studies on the Determination of Renin in Rat Kidney
• The Solid-phase Synthesis of Ile5-Angiotensin II to Demonstrate the Use of Nim-Tosyl-histidine
• Pharmacodynamic and pharmacokinetic studies on prizidilol and nipradilol (K-351), antihypertensive drugs with combined vasodilator and .BETA.-adrenoceptor blocking actions, in rabbits.
• Oxytocin Analogues Containing No Disulfide Bond. III. The Synthesis of Three Analogues of 1,6-Aminosuberic Acid-Oxytocin
• Enzyme-Linked Immunoassay for Midkine, and Its Application to Evaluation of Midkine Levels in Developing Mouse Brain and Sera from Patients with Hepatocellular Carcinomas.
• The Synthesis of a Series of N-t-Amyloxycarbonyl-oligo-L-proline

もっと見る 閉じる

スポンサーリンク