The Synthesis of a Series of <I>N</I>-<I>t</I>-Amyloxycarbonyl-oligo-L-proline
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概要
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A series of <I>N</I>-protected L-proline oligomers, the di-, tri-, tetra-, penta-, hexa- and octamer, were synthesized by conventional methods. The proline imino-group was protected by the <I>t</I>-amyloxycarbonyl (Aoc) group, and the carboxyl group was protected as the benzyl ester during the synthesis. These Aoc-oligoprolines were valuable in elucidating the relationship between the conformation and the degree of polymerization of the polyprolines. The Aoc-protecting group was useful in purifying the intermediates and in obtaining crystals of the final compounds.
- 公益社団法人 日本化学会の論文
著者
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Sakakibara Shumpei
Peptide Center, Institute for Protein Research, Osaka University
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Kimura Terutoshi
Peptide Center, Institute for Protein Research, Osaka University
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