Oxytocin Analogues Containing No Disulfide Bond. III. The Synthesis of Three Analogues of 1,6-Aminosuberic Acid-Oxytocin
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概要
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[Asu<SUP>1,6</SUP>]-oxytocin, an analogue of deamino-oxytocin in which the disulfide bond is replaced by an ethylene linkage, is completely resistant to deterioration during storage under concentrated conditions. In the present study, three new analogues of this material, [Phe<SUP>3</SUP>, Asu<SUP>1,6</SUP>]-oxytocin, [Val<SUP>4</SUP>, Asu<SUP>1,6</SUP>]-oxytocin, and [Gly<SUP>7</SUP>, Asu<SUP>1,6</SUP>] -oxytocin, were synthesized to find out a hormonal compound possessing a specifically higher uterotonic activity. Among them, the [Gly<SUP>7</SUP>]-analogue was found to be the most promising compound; it showed a relatively higher uterotonic activity (245 IU/mg) in the rat, with a faint antidiuretic activity (0.02 IU/mg) and a weak depressor activity.
- 公益社団法人 日本化学会の論文
著者
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Sakakibara Shumpei
Peptide Center, Institute for Protein Research, Osaka University
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Yamanaka Tsutomu
Peptide Institute, Protein Research Foundation
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