Studies on the Synthesis of Histidine Peptides. I. <I>N</I><SUP>im</SUP>-Tosylhistidine Derivatives as Starting Materials
スポンサーリンク
概要
- 論文の詳細を見る
<I>N</I><SUP>α</SUP>-Nps-, Z(OMe)-, Z-, Boc-, and Aoc-derivatives of <I>N</I><SUP>im</SUP>-tosylhistidine were synthesized as materials for the syntheses of histidine-containing peptides, and the reactivity of the <I>N</I><SUP>im</SUP>-tosyl group was examined under several conditions commonly used for peptide syntheses. Although the <I>N</I><SUP>im</SUP>-tosyl group was somewhat more unstable than <I>N</I><SUP>im</SUP>-benzyl group, the use of the tosyl derivative was found to be advantageous in several points: the enhancement of the solubility of its peptide derivatives, the suppressive effect of racemization during its coupling reactions, and the high removability of the tosyl group under mild conditions.
- 公益社団法人 日本化学会の論文
著者
-
SAKAKIBARA SHUMPEI
Peptide Institute, Protein Research Foundation
-
Sakakibara Shumpei
Peptide Center, Institute for Protein Research, Osaka University
-
Fujii Toshiyuki
Peptide Institute, Protein Research Foundation
-
Fujii Toshiyuki
Peptide Center, Institute for Protein Research, Osaka University
関連論文
- Molecular Mechanism of Action by Atrial Natriuretic Peptide in Rat Vascular Smooth Muscle Cells : SYMPOSIUM ON ATRIAL NATRIURETIC POLYPEPTIDE (ANP): Basic and Clinical Research : 51th Annual Scientific Session of the Japanese Circulation Society
- Enzyme-Linked Immunoassay for Midkine, and Its Application to Evaluation of Midkine Levels in Developing Mouse Brain and Sera from Patients with Hepatocellular Carcinomas
- Total Synthesis of Aequorea Green Fluorescent Protein
- Chemical Synthesis of Dendrotoxin I : Revision of the Reported Structure
- Solution Synthesis of Calcicludine (CaC) : A Potent Blocker of an L-subtype of Neuronal Ca^ Channels
- Smooth Muscle Relaxing and Hypotensive Activities of Synthetic Calciseptine and the Homologous Snake Venom Peptide FS_2
- Amino Acid Sequence of Sardine Calcitonin and Its Hypocalcemic Activity in Rats
- Solution Structure of α-Conotoxin SI Determined by Two-Dimensional NMR Spectroscopy
- High Performance Liquid Chromatography of Bradykinin and Its Application to the Degradation Study of Bradykinin in Plasma (生体成分の高速液体クロマトグラフィ-)
- Application of N^-Cyclohexyloxycarbonyltryptophan to Peptide Synthesis
- Toward the Total Synthesis of Proteins
- SPECIFIC PRESSOR ACTIVITY OF ANGIOTENSINS I AND II
- SPECIFIC PRESSOR ACTIVITY AND STABILITY OF SYNTHETIC ANGIOTENSINS
- The presence of substance P carboxy-terminal heptapeptide in pig brain stem.
- A New Protective Group Suitable for Masking Specific Amino Groups during Peptide Synthesis
- Studies on the Synthesis of Histidine Peptides. I. Nim-Tosylhistidine Derivatives as Starting Materials
- The Solid-phase Synthesis of Ile5-Angiotensin II to Demonstrate the Use of Nim-Tosyl-histidine
- Oxytocin Analogues Containing No Disulfide Bond. III. The Synthesis of Three Analogues of 1,6-Aminosuberic Acid-Oxytocin
- Enzyme-Linked Immunoassay for Midkine, and Its Application to Evaluation of Midkine Levels in Developing Mouse Brain and Sera from Patients with Hepatocellular Carcinomas.
- The Synthesis of a Series of N-t-Amyloxycarbonyl-oligo-L-proline