Synthesis of Amyloid β-Peptides in Solution : Chloroform- Phenol Mixed Solvent Is Essential for Segment Condensation of Sparingly Soluble Protected Peptides

スポンサーリンク

概要

• 論文の詳細を見る
• 2000-03-01

著者

• 小嶋 哲人

  Department Of Transfusion Medicine Cardiology And Hematology Nagoya University Hospital

• 小嶋 哲人

  名古屋大学医学部第一内科

• 小嶋 哲人

  名古屋大学 保健

• Kimura T

  Peptide Institute Inc. Protein Research Foundation

• Kojima Tetsuhito

  名古屋市立大学 医学系研究科血液腫瘍内科学

• NISHIUCHI Yuji

  Peptide Institute Inc.

• INUI Tatsuya

  Department of Physics, Kyoto University

• Inui Tatsuya

  Department Of Physics Faculty Of Science Kyoto University

• Inui Tatsuya

  Peptide Institute Inc. Protein Research Foundation

• KIMURA TERUTOSHI

  Peptide Institute Inc., Protein Research Foundation

• Nishio Hideki

  Peptide Institute Inc. Protein Research Foundation

• Nishiuchi Y

  Peptide Institute Inc. Protein Research Foundation

• Inui Tatsuya

  Department Of Physics Kyoto University

• Kimura Terutoshi

  Peptide Institute Inc.

• Inui Tatsuya

  Department of Physics, Faculty of Science, Kyoto University

• Kimura Terutoshi

  Peptide Center, Institute for Protein Research, Osaka University

関連論文

• 日本人の血栓性素因
• 白血病細胞株を用いた巨核芽球系分化誘導モデルにおけるヒトスフィンゴシンキナーゼ1発現機序の解析
• Long-PCR 法を用いた血液凝固第 VIII 因子 遺伝子の逆位解析
• 尿中HIV抗体検査の臨床的有用性に関する研究-全国11施設による協同研究-
• プロテイン S 欠乏症
• 原因不明の出血を初発症状とし,心症状が進行性に出現し死亡した71歳男性
• Activated protein C resistance in the Japanese population due to homozygosity for the factor V R2 haplotype
• Stress-induced PAI-1 expression is suppressed by pitavastatin in vivo
• Definite diagnosis in Japanese patients with protein C deficiency by identification of causative PROC mutations
• Mutational analysis of SOS1 gene in acute myeloid leukemia
• Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis
• Wilms' tumor 1 message and protein expression in bone marrow failure syndrome and acute leukemia
• Mutated RAS Induced PLD1 Gene Expression through Increased Sp1 Trascription Factor
• Recurrent Mutations of Factor XI Gene in Japanese
• シンポジウム3 血栓症への新しいアフローチ血栓症の分子細胞学的基礎-プロテインC, プロテインS欠損症を例として-
• プロテインC-Nagoyaにおける分泌異常の解析
• 日本人血友病BのDNAポリモルフィズムを用いた保因者ならびに出生前遺伝子診断
• 第VIII因子遺伝子逆位解析の重症血友病Aにおける保因者診断, 出生前診断への応用
• ジーンターゲティングを用いた血液凝固制御因子の生体における機能解明 : マウスantithrombinの完全欠損による胎児死亡とsyndecan-4欠損による胎盤迷路層胎児血管の変性
• Recurrent Intramural Hematoma of the Small Intestine in a Severe Hemophilia A Patient with a High Titer of Factor VIII Inhibitor : A Case Report and Review of the Literature
• High Titer of ADAMTS13 Inhibitor Associated with Thrombotic Microangiopathy of the Gut and Skeletal Muscle after Allogeneic Hematopoietic Stem Cell Transplantation
• Effect of Hydration on the Thermal Stability of the Collagen Model Peptide Containing 4(S)-Hydroxyproline
• Stabilizing Mechanism of Collagen-like Triple Helical Structure of (4(R)-Hydroxyprolyl-4(R)-hydroxyprolyl-glycine)_
• Effects of Proline Substitution on the Thermal Stability and Hydration of Collagen Triple Helix
• Synthesis and Thermal Stability of New Collagen Model Peptides Containing 4-Hydroxyproline and 4-Fluoroproline
• Stabilization of Triple Helical Structure of Collagen Molecule
• ヒトRyudocan分子の精製と生物学的機能解析
• Clinical Trial to Investigate the Pharmacokinetics, Pharmacodynamics, Safety, and Efficacy of Recombinant Factor VIIa in Japanese Patients With Hemophilia With Inhibitors
• Orbital Calibration of the XIS(Chapter 12. Instructions of Suzaku Data Analysis, The Extreme Universe in the Suzaku Era)
• Molecular Superbubbles and Outflows from the Starburst Galaxy NGC 2146
• Molecular Cloning, Genomic Organization, Promoter Activity, and Tissue-Specific Expression of the Mouse Ryudocan Gene^1
• 生理的抗血栓分子のノックアウトマウス解析
• 教育シンポジウム:がんの遺伝子診断 PCRを用いた遺伝子診断の原理と応用-血友病Bを例にして-
• Iron and Nickel Line Diagnostics for the Galactic Center Diffuse Emission
• Development of Spontaneously Regenerable Water-Soluble Prodrugs Based on the Peptide Chemistry : Importance of Drug Release Time for the Improvement of Gastrointestinal Absorption
• Clusters of Basic Amino Acids in Midkine: Roles in Neurite-Promoting Activity and Plasminogen Activator-Enhancing Activity^1
• Enzyme-Linked Immunoassay for Midkine, and Its Application to Evaluation of Midkine Levels in Developing Mouse Brain and Sera from Patients with Hepatocellular Carcinomas
• M82 X-1 : The Hyper Luminous X-Ray Source(Session 2 : ULXs and Intermediate-Mass BHs)
• 先天性凝固阻止因子欠乏症(antithrombin, protein C, protein S 欠損症)
• Chandra Observation of the Starburst Galaxy NGC 2146
• 血栓性素因部会 : 血栓性素因・プロテインS欠乏症/欠損症をめぐる最近の話題
• 血液凝固亢進状態の抗凝固療法
• Severe hemophilia A in a Japanese female caused by an F8-intron 22 inversion associated with skewed X chromosome inactivation
• Classic Polyarteritis Nodosa Presenting Rare Clinical Manifestations in a Patient with Hemophilia A
• AT/DS併用によるエンドトキシン誘発臓器傷害の改善効果 : Antithrombin/danaparoid sodium の抗凝固薬としての位置付け
• Identification of the regulatory elements of the human von Willebrand factor for binding to platelet GPIb. Importance of structural integrity of the regions flanked by the CYS1272-CYS1458 disulfide bond
• Identification of six novel MYH9 mutations and genotype-phenotype relationships in autosomal dominant macrothrombocytopenia with leukocyte inclusions
• Identification of plasma antibody epitopes and gene abnormalities in Japanese hemophilia a patients with factor VIII inhibitor
• Optimization of the Oxidative Folding Reaction and Disulfide Structure Determination of Multiple-Cystine Peptides
• Modifications Associated with Use of the Benzyloxymethyl Group on Histidine
• Chemical Synthesis of Human β-Defensin (hBD)-1,2,3 and 4 : Optimization for Folding Reduced hBDs into a Native Conformation
• Synthesis and Disulfide Structure Determination of Muscarinic Toxin 3
• Synthesis of Amyloid β-Peptides by Employing a Convergent Solid-Phase Approach Performed in a Mixture of Chloroform and Phenol
• Synthesis and Disulfide Structure Determination of Kurtoxin, a T-type Calcium Channel Blocker
• Synthesis of Prokineticin 2 by Solid-Phase Approach Performed in a Chloroform-Phenol Mixed Solvent
• Synthesis of Human Leptin Employing a Combined Solid-Phase and Solution Approach
• Optimization of Segment Condensation Reactions of Sparingly Soluble Protected Peptides in Chloroform-Phenol Mixed Solvent
• Side Reaction Associated with Use of N^in-Cyclohexyloxy- carbonyl (Hoc) Group for Tryptophans during HF Deprotection
• Synthesis of Muscarinic Toxin 1 and 7 Possessing High Specificity for Muscarinic Acetylcholine Receptor Subtype
• Amino Acid Deletion Products Resulting from Incomplete Deprotecion of the Boc Group during Solid-Phase Peptide Synthesis
• Synthesis of Amyloid β-Peptides in Solution : Chloroform- Phenol Mixed Solvent Is Essential for Segment Condensation of Sparingly Soluble Protected Peptides
• New Powerful Solvent System, A Mixture of Chloroform and Phenol, for Segment Condensation of Sparingly Soluble Protected Petides
• Total Synthesis of Aequorea Green Fluorescent Protein
• Expression of Syndecan-1 and -3 during Embryogenesis of the Central Nervous System in Relation to Binding with Midkine^1
• Chemical Synthesis of Dendrotoxin I : Revision of the Reported Structure
• Solution Synthesis of Calcicludine (CaC) : A Potent Blocker of an L-subtype of Neuronal Ca^ Channels
• Discoveries of Diffuse Iron Line Sources from the Sgr B Region
• Solution Structure of α-Conotoxin SI Determined by Two-Dimensional NMR Spectroscopy
• 血友病の遺伝子異常と遺伝子診断
• Genetic Abnormalities of Bernard-Soulier Syndrome
• The Solution Structure of Leginsulin, a Plant Hormone with Insulin-Like Activity, by Nuclear Magnetic Resonance Spectroscopy
• Interaction between Archaeal FKBP and Peptide Substrate
• 2P-005 ニンジンレグインスリン結合タンパク質の結晶構造(蛋白質-構造,第47回日本生物物理学会年会)
• Helix-Coil Transition of Glu_-Ala_ as Studied by CD and NMR Spectroscopy
• Transient role of CD4^+CD25^+ regulatory T cells in mycobacterial infection in mice
• Substrate Transition-State Analogue Inhibitors of Plasmepsin II as Antimalarial Drugs
• An Approach for Peptidic Aspartic Protease Inhibitors Using Ala-containing Oligopeptides Independent of the Substrate Sequence
• Structure-Activity Relationships of Nocistatin, A Novel Peptide Blocking Nociceptin Action in Pain Transmission
• Structure-Migration Rate Relationship of Water-Soluble Prodrugs of HIV-1 Protease Inhibitors Based on O→N Intramolecular Acyl Migration
• Development of a New Synthetic Method for L-Tetrahydrofuranylglycine and Its Application for Substrate-based HIV-1 Protease Inhibitors
• Syntheses of Stem Peptides of Bacterial Cell Walls with Proinflammatory Activity
• Chloroform-Phenol Mixed Solvent Essential for Segment Condensation Reaction on a Solid Support
• Synthesis of Marinostatin, an Ester-Linked Protein Protease Inhibitor from the Marine Bacterium Pseudoalteromonas sagamiensis
• Suppression of Side Reactions during Final Deprotection Employing a Strong Acid
• Three-Dimensional Structure Analysis of the Selenium Complexes of Phytochelatin Analog
• 東北地方における血友病インヒビター調査のまとめ
• Virus-Associated Hemophagocytic Syndrome Caused by Pandemic Swine-Origin Influenza A (H1N1) in a Patient After Unrelated Bone Marrow Transplantation
• Thermodynamic analysis of PPARγ-ligand interaction
• Application of N^-Cyclohexyloxycarbonyltryptophan to Peptide Synthesis
• 抗Xa薬 (凝固制御) -- (抗凝固薬の新展開)
• エストロゲンによるProtein S産生抑制
• ヘパラン硫酸プロテオグリカン・Ryudocanノックアウトマウスの作製・解析
• 日本人の血栓性素因、特にプロテインS欠損症を中心に
• 血栓性素因の病因と病態
• 新規抗凝固薬
• von Willebrand病に合併した未破裂脳動脈瘤に対してコイル塞栓術を行った１例：症例報告
• 新規血栓性素因・アンチトロンビン抵抗性遺伝子異常
• Anticoagulant therapy for hyper coagulation state
• Gene analysis of the congenital thrombophilia –present and future–
• エストロゲンによる Protein S 産生抑制

もっと見る 閉じる

スポンサーリンク