Sympathetic Nervous Activity in Renal and DOC Hypertensive Rats
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概要
- 論文の詳細を見る
The sympathetic tone of the splanchnic nerve was quantified in renal and deoxycorticosterone (DOG) hypertensive rats under pentobarbital anesthesia by measuring equivalent stimulation frequency (ESF). ESF is the frequency of stimulus to the peripheral cut end of the nerve required to restore the preseverance level of arterial pressure. It is assumed to represent the average discharge rate of the nerve before severance. ESF was markedly increased in DOG hypertension 2 weeks after initiation of the DOC-salt treatment. It was relatively decreased after 10 weeks, but was still higher than in the controls. In renal hypertension (clipping of the left renal artery), ESF was decreased considerably 2 weeks and slightly 10 weeks after clipping. When the contralateral kidney had been removed simultaneously with clipping (clip+uninephrectomy), ESF was not sig-nificantly changed. It is suggested that the sympathetic nervous system participates greatly in the pathogenesis of DOC hypertension but not of renal hypertension.
- International Heart Journal刊行会の論文
著者
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Mizogami Susumu
Department Of Pharmacology Toho University School Of Medicine:(presuent Address)research Laboratory
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Sokabe Hirofumi
Department Of Parmacology Toho University Shool Of Medicine
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Iriuchijima Juro
Department Of Physiology Faculty Of Medicine University Of Tokyo
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SOKABE Hirofumi
Department Physiology, Faculty of Medicine, University of Tokyo
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IRIUCHIJIMA Juro
Department of Physiology and Institute of Medical Electronics, Faculty of Medicine, University of Tokyo
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IRIUCHIJIMA Juro
Department Physiology, Faculty of Medicine, University of Tokyo
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SOKABE Hirofumi
Departine rt of Pharmacology, Jichi Medical School
関連論文
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