Effect of Clonidine on Sympathetic Discharge Rate of Spontaneously Hypertensive Rats

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概要

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• Clonidine or Catapres at a dose of 5μg/Kg was administered intravenously to spontaneously hypertensive rats (SHR) at 16 weeks of age under pentobarbital anesthesia. The mean arterial pressure was lowered from 138±4mm Hg (mean±SEM, n=6) to 100±5 and the heart rate from 350±9/min to 299±14. The mean discharge rate of vasoconstrictor fibers of the splanchnic nerve estimated by cutting and stimulating the nerve was 0.33±0.09/sec for the right splanchnic nerve and 0.90±0.27/sec for the left splanchnic nerve (after severance of the right nerve). These values were significantly (P<0.005 and 0.001, respectively) lower than the corresponding values in untreated SHR and comparable with those in normotensive control rats. The concomitant decrease in arterial pressure and sympathetic discharge rate confirms that the major contribution to hypertension of SHR is by elevation of the sympathetic tone.

• International Heart Journal刊行会の論文

著者

• Iriuchijima Juro

  Department Of Physiology Faculty Of Medicine University Of Tokyo

関連論文

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• Effect of Increasing Age on Hemodynamics of Spontaneously Hypertensive Rats
• Hemodynarnics of Spontaneously Hypertensive Rats in Conscious State
• Sympathetic Nervous Activity in Renal and DOC Hypertensive Rats
• Distribution of Cardiac Output in Conscious Animals : SIMPOSIUM ON EXPERIMENTAL AND CLINICAL TOPICS IN THE REGULATION OF THE CIRCULATION
• Measurement of Aortic Compliance in Vivo
• Role of Splanchnic Nerves in Spontaneously Hypertensive Rats
• Effect of Clonidine on Sympathetic Discharge Rate of Spontaneously Hypertensive Rats
• Sympathetic Discharge Rate in Spontaneously Hypertensive Rats
• Effects of Nitrites on Arterial Collateral Vessels of Dogs

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