Effects of enalapril and captopril on urinary excretion of kinins and electrolytes in stroke-prone spontaneously hypertensive rats.
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概要
- 論文の詳細を見る
Urinary excretion of kinins in stroke-prone spontaneously hypertensive (SHRSP) rats was unchanged during oral enalapril (10 mg/kg) or captopril (30 mg/kg) treatment once a day for 8 days compared to vehicle treatment. However, a significant decrease in urinary kinin excretion was observed on the 5th and 7th day compared to the pretreatment value in rats treated with enalapril. Both enalapril and captopril produced a significant reduction in blood pressure when compared to the vehicle. These findings provide no positive evidence to support the hypothesis of possible involvement of renal kinins in the antihypertensive effect of converting enzyme inhibitors in SHRSP rats.
- 公益社団法人 日本薬理学会の論文
著者
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KAWASHIMA Koichiro
Department of Pharmacology, Kyoritsu College of Pharmacy
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WATANABE Takushi
Departine rt of Pharmacology, Jichi Medical School
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SOKABE Hirofumi
Departine rt of Pharmacology, Jichi Medical School
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KAWASHIMA Koichiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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KIMURA Miyako
Department of Pharmacology, Kyoritsu College of Pharmacy
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KOBAYASHI Yuji
Special Reference Laboratory
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