Vasodepressor Effect of Atrial Natriuretic Peptides in the Quail, Coturnix coturnix japonica : Endocrinology
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概要
- 論文の詳細を見る
An intravenous injection of α-human atrial natriuretic peptide-(1-28) (α-hANP) caused dose-dependent decreases in both arterial pressure and heart rate in the urethane-anesthetized quail. The hypotension always preceded the bradycardia. The ED_<50> for the vasodepressor effect (58.2±4.6 pmol/100g, n=28) was smaller than that for the bradycardial effect (107.2±8.9 pmol/100g, n=23). The hANP peptides with 3-6 amino acids removed from the NH_2-terminus were as potent as α-hANP, but the peptide with 4 amino acids removed from the COOH-terminus had only about half the vasodepressor potency of the parent molecule. Among the peptides of hANP in which an amino acid within the ring structure was modified, only des-Gly^9 hANP, [(Met (O)^<12>]hANP, and [Asn^<13>]hANP had decreased the potency. Formation of the ring structure between the 7th and the 23rd position with an ethylene linkage instead of a disulfide bond did not change the potency. These results suggest that the amino acid residues at the COOH-terminus and some amino acids within the ring structure of hANP are important for the expression of its vasodepressor activity in the quail.
- 社団法人日本動物学会の論文
- 1990-06-15
著者
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Watanabe T
Peptide Inst. Inc. Osaka Jpn
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TAKEI YOSHIO
Department of Physiology, Kitasato University School of Medicine
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Takei Y
Ocean Research Institute University Of Tokyo
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Takei Yoshio
Division Of Marine Bioscience Ocean Research Institute The University Of Tokyo
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Takei Yoshio
Ocean Research Institute University Of Tokyo
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Takei Yoshio
Department Of Physiology Ocean Research Institute The University Of Tokyo
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WATANABE TAKUSHI
Department of Physiology, Kitasato University School of Medicine
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Takei Yoshio
Laboratory Of Physiology Department Of Marine Bioscience Ocean Research Institute The University Of
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Watanabe Takushi
Department Of Pharmacology Jichi Medical School
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Takei Yoshio
Department Of Physiology Kitasato University School Of Medicine
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Takei Yoshio
Department Of Pathology Division Of Neuropathology Emory University School Of Medicine
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WATANABE Takushi
Departine rt of Pharmacology, Jichi Medical School
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