Renal Lesions of Streptozotocin-Induced Diabetes Mellitus in Spontaneously Hypertensive Rats
スポンサーリンク
概要
- 論文の詳細を見る
Spontaneously hypertensive rats (SHR), unilaterally nephrectomized, and treated with 30mg/kg streptozotocin (STZ), i.v., showed sustained high blood glucose (>200mg/dl) and pressure (>160mmHg) during 6 to 12-week-observation. Glomerular exudative and medial proliferative changes were seen in the kidney. Thus, an animal model of diabetic nephropathy with hypertension has been established. Moreover, hypertension was not observed in Wistar-Kyoto (WKY) or normal Wistar (WR) rats after STZ treatment. Existance of so-called STZ hypertension in the rat is suspicious.
- International Heart Journal刊行会の論文
著者
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Kishi Koichiro
Department Of Legal Medicine And Molecular Genetics Gunma University Graduate School Of Medicine
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Yagi Shigeru
Department Of Medicine And Laboratory Of Medical Science
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SOKABE Hirofumi
Departine rt of Pharmacology, Jichi Medical School
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Kusaka Miho
Department of Pharmacology, Jichi Medical School
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Miyazawa Atsuko
Departments of Ophtalmology, Jichi Medical School
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