NEW INTERPRETATION OF SYSTOLIC TIME INTERVALS FROM ACTIVE CROSS-BRIDGE MODEL
スポンサーリンク
概要
- 論文の詳細を見る
Using an active cross-bridge model proposed by the authors, it has been established theoretically that cross-bridge activation rate (K_a) of the left ventricular myocardium, which might correspond to the rate of binding of Ca^<2+> with troponin C, is approximately expressed as a simple formula: K_a=3/electromechanical systole (sec^<-1>), although no definitive biological proof has yet been provided for the equation. One hundred eighteen patients without significant cardiac disease and 6 patients who had atrioventricular block with a permanent pacemaker were evaluated to determine the K_a value of the normal human left ventricular myocardium (test 1), and to examine the effect of changes in heart rate (test 2) as well as afterloading (test 3) or dobutamine infusion (test 4) on K_a. The pacing rate was increased from 50 to 110 beats/min at 20-beat increments in test 2. Arterial pressure was elevated by angiotensin 11 infusion in test 3, and 7 subjects received a continuous dobutamine infusion in test 4. The K_a value was found to be related to heart rate, to be increased by dobutamine infusion, and to be decreased by myocardial lengthening due to afterloading. Dependence of K_a on heart rate appeared to result from changes in myocardial length. The K_a value corrected for heart rate (K_<ac>) had an average variation of only 4.6%, and was unrelated to age or myocardial length in individual subjects. Thus, the K_<ac> value of normal human left ventricular myocardium appears to be nearly constant between individuals but to be increased by catecholamine infusion or myocardial shortening.
- 社団法人日本循環器学会の論文
- 1993-04-20
著者
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TAKAHASHI Masaki
Department of Medicine, Kidney Center, Tokyo Women's Medical University
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KONO Koichi
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University
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Tamano Kouichi
Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine
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MASUDA Toshihide
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University
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Nakamura Yasuyuki
Department of Cardiovascular Epidemiology, Kyoto Women's University
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Tamano Kouichi
Department Of Hypertension And Cardiorenal Medicine Dokkyo University School Of Medicine
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Takeda Kouichi
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of
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Takeda Kouichi
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo Universlty School Of
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Yagi Shigeru
Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo Universlty School o
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Yagi Shigeru
Utsunomiya Central Hospital
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Takahashi Masaki
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University
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Yagi Shigeru
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo Universlty School Of
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HOSOYA KAZUYOSHI
Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo University School o
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YOSHIHARA TERUE
Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo University School o
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Yoshihara Terue
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of
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Kono Koichi
Department Of Hygiene And Public Health I・ii Osaka Medical College
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Kono Koichi
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of
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Masuda Toshihide
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of
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Masuda Toshihide
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University
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Yagi Shigeru
Department Of Medicine And Laboratory Of Medical Science
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Hosoya Kazuyoshi
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of
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Nakamura Yasuyuki
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of
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Takahashi Masaki
Department Of Analytical Biochemistry Meiji Pharmaceutical University
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Nakamura Yasuyuki
Department Of Biological Science And Technology Science University Of Tokyo
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Yagi Shigeru
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of Medicine
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Takeda Kouichi
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of Medicine
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TAKEDA KOUICHI
Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo University School of Medicine
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TAKAHASHI Masaki
Department of Agricultural Chemistry, Faculty of Agriculture, Tohoku University
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NAKAMURA Yasuyuki
Department of Agricultural Chemistry, Faculty of Agriculture, Niigata University
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Takeda Kouichi
Department of Engineering Science, The University of Electro-Communications, Chofu, Tokyo 182-8585, Japan.
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