EFFECT OF α_1-ADRENOCEPTOR BLOCKADE ON THE LEFT VENTRICULAR FORCE-LENGTH RELATIONSHIP IN DOGS
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概要
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We used the left ventricular (LV) end-systolic force-diameter (F_<es>-D_<es>) relation to evaluate the effect of an alpha_1-adrenoceptor antagonist (bunazosin hydrochloride) on the contractility of the beta-blocked left ventricle. Nine adult mongrel dogs were instrumented with ultrasonic crystals to measure LV diameter and a micromanometer to measure LV pressure. Beta-adrenergic and vagal blockade was induced with intravenous propranolol (2 mg/kg) and atropine (0.2 mg/kg), respectively, and preload was decreased by inferior vena caval occlusion. The slope (E_c) and extrapolated diameter intercept (D_o) of the LV F_<es>-D_<es> relation were derived from end-systolic data obtained in the control state (after beta-blockade) and after bunazosin infusion (1 mg/kg). E, was used as a new index of LV contractility. After bunazosin infusion, the heart rate and E_c were decreased by 7 and 22%, respectively, in comparison with the control state, whereas D_o did not change. These results indicate that alpha_1-adrenoceptor blockade significantly reduces myocardial contractility in the beta-blocked canine heart, perhaps by decreasing the intracellular calcium concentration and/or myosin ATPase activity.
- 社団法人日本循環器学会の論文
- 1992-09-20
著者
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TAKAHASHI Masaki
Department of Medicine, Kidney Center, Tokyo Women's Medical University
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KONO Koichi
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University
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MASUDA Toshihide
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University
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Nakamura Yasuyuki
Department of Cardiovascular Epidemiology, Kyoto Women's University
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Takeda Kouichi
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of
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Shimizu Takahiko
Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology
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Takeda Kouichi
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo Universlty School Of
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Yagi Shigeru
Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo Universlty School o
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OYAMA Makoto
Department of Applied Biochemistry, Utsunomiya University
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Shimizu Takahiko
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of
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Takahashi Masaki
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University
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Yagi Shigeru
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo Universlty School Of
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Oyama Makoto
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of
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Oyama Makoto
Department Of Applied Biochemistry Utsunomiya University
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Kono Koichi
Department Of Hygiene And Public Health I・ii Osaka Medical College
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Kono Koichi
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of
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Masuda Toshihide
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of
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Masuda Toshihide
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University
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Yagi Shigeru
Department Of Medicine And Laboratory Of Medical Science
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Shimizu Takahiko
Department Of Aging Control Medicine Juntendo University Graduate School Of Medicine
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Nakamura Yasuyuki
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of
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Takahashi Masaki
Department Of Analytical Biochemistry Meiji Pharmaceutical University
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Shimizu Takahiko
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of
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Nakamura Yasuyuki
Department Of Biological Science And Technology Science University Of Tokyo
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Yagi Shigeru
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of Medicine
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Takeda Kouichi
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of Medicine
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TAKEDA KOUICHI
Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo University School of Medicine
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TAKAHASHI Masaki
Department of Agricultural Chemistry, Faculty of Agriculture, Tohoku University
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NAKAMURA Yasuyuki
Department of Agricultural Chemistry, Faculty of Agriculture, Niigata University
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Takeda Kouichi
Department of Engineering Science, The University of Electro-Communications, Chofu, Tokyo 182-8585, Japan.
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