Structure of β-Amyloid Fibrils and Its Relevance to Their Neurotoxicity : Implications for the Pathogenesis of Alzheimer's Disease

スポンサーリンク

概要

• 論文の詳細を見る

• Alzheimer's disease and cerebral amyloid angiopathy are characterized by the deposition of β-amyloid fibrils consisting of 40- and 42-mer peptides (Aβ40 and Aβ42). Since the aggregation (fibrilization) of these peptides is closely related to the pathogenesis of these diseases, numerous structural analyses of Aβ40 and Aβ42 fibrils have been carried out. Aβ42 plays a more important role in the pathogenesis of these diseases since its aggregative ability and neurotoxicity are considerably greater than those of Aβ40. This review summarizes mainly our own recent findings from the structural analysis of Aβ42 fibrils and discusses its relevance to their neurotoxicity in vitro.

• 社団法人日本生物工学会の論文
• 2005-05-25

著者

• TAKEGOSHI Kiyonori

  Department of Chemistry, Graduate School of Science, Kyoto University

• OHIGASHI Hajime

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• Takegoshi Kiyonori

  Graduate School Of Science Kyoto University

• Shirasawa Takuji

  Department of Aging Control, Graduate School of Medicine, Juntendo University School of Medicine

• Ohigashi H

  Department Of Surgery Osaka Medical Center For Cancer And Cardiovascular Diseases

• Ohigashi Hiroaki

  Department Of Surgery The Center For Adult Diseases

• 入江 一浩

  京都大学農学部

• 入江 一浩

  京都大学 食品工学

• 入江 一浩

  京都大学 農

• 入江 一浩

  京都大学大学院農学研究科食品生物科学

• Ohigashi H

  Graduate School Of Agriculture Kyoto University

• Ohigashi H

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Shimosawa Tatsuo

  Molecular Gerontology Tokyo Metropolitan Institute Of Gerontology

• Irie Kazuhiro

  京都大学 農学研究科

• Shimizu Takahiko

  Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology

• Ohigashi Hajime

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• NAGAO Masaya

  Graduate School of Biostudies, Kyoto University

• IRIE KAZUHIRO

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• MURAKAMI KAZUMA

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• MASUDA YUICHI

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• MORIMOTO AKIRA

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• OHASHI RYUTARO

  Department of Chemistry, Graduate School of Science, Kyoto University

• NAGAO MASAYA

  Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University

• Nagao Masaya

  Graduate School Of Biostudies Kyoto University

• Nagao Masaya

  Division Of Integrated Life Science Graduate School Of Biostudies Kyoto University

• Murakami Kazuma

  Graduate School Of Agriculture Kyoto University

• Shimizu Takahiko

  東京都老人総合研究所 老人バイオマーカー研究

• Shirasawa Takuji

  Research Team For Molecular Biomarkers Tokyo Metropolitan Istitute Of Gerontology

• Shirasawa Takuji

  Department Of Molecular Gerontology Tokyo Metropolitan Institute Of Gerontology

• Morimoto Akira

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• Nagao M

  Graduate School Of Biostudies Kyoto University

• Irie Kazuhiro

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• Masuda Yuichi

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• Takegoshi Kiyonori

  Department Of Chemistry Graduate School Of Science Kyoto University

• Shirasawa Takuji

  Department Of Aging Control Medicine Juntendo University Graduate School Of Medicine

• Ohashi Ryutaro

  Department Of Chemistry Graduate School Of Science Kyoto University

• 入江 一浩

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• Shimizu Takahiko

  Department Of Aging Control Medicine Juntendo University Graduate School Of Medicine

• Shirasawa Takuji

  Department Of Ageing Control Juntendo University Graduate School Of Medicine

• Nakayama Mizuho

  Unit Of Anatomy And Cell Biology Department Of Animal Sciences Kyoto University

• Shimosawa Tatsuo

  Faculty Of Medicine The University Of Tokyo

• Murakami Kazuma

  Department Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

関連論文

• Chemically Nonequivalent Sites in Mesoporous BCN Revealed by Solid-state NMR at 21.8T
• Lack of Enhancing Effect of Lauric Acid on the Development of Aberrant Crypt Foci in Male ICR Mice Treated with Azoxymethane and Dextran Sodium Sulfate
• Age and Sex-Dependent Alterations in Heart Rate Variability : Profiling the Characteristics of Men and Women in Their 30s
• EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth
• Novel tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4
• Usefulness of the CLIP scoring system for prediction of postoperative prognosis of patients with large hepatocellular carcinoma
• Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis
• Over-expression of cysteine proteinase inhibitor cystatin 6 promotes pancreatic cancer growth
• Periodic Ultrasonography Checkup for the Early Detection of Pancreatic Cancer : Preliminary Report
• Unusual Atrophic Change After Repeated Arterial Therapy for Hepatocellular Carcinoma : Report of a Case
• Acinar Cell Carcinoma of the Pancreas Successfully Treated by En Bloc Resection and Intraperitoneal Chemotherapy for Peritoneal Relapse : A Case Report of a 15-Year Survivor
• 1995年度日本農芸化学会大会【encircled 1】
• Combinatorial Effects of Nonsteroidal Anti-inflammatory Drugs and Food Constituents on Production of Prostaglandin E_2 and Tumor Necrosis Factor-α in RAW264.7 Murine Macrophages(Food & Nutrition Science)
• Anti-tumor Promoting Activity of Bufadienolides from Kalanchoe pinnata and K.daigremontiana×tubiflora
• In Vitro Absorption and Metabolism of Nobiletin, a Chemopreventive Polymethoxyflavonoid in Citrus Fruits
• An Avocado Constituent, Persenone A, Suppresses Expression of Inducible Forms of Nitric Oxide Synthase and Cyclooxygenase in Macrophages, and Hydrogen Peroxide Generation in Mouse Skin
• Inhibition by (-)-Persenone A-related Compounds of Nitric Oxide and Superoxide Generation from Inflammatory Leukocytes
• Screening for the In Vitro Anti-tumor-promoting Activities of Edible Plants from Malaysia
• Identification of Zerumbone in Zingiber zerumbet Smith as a Potent Inhibitor of 12-O-Tetradecanoylphorbol-13-acetate-induced Epstein-Barr Virus Activation
• Inhibitory Effects of Curcumin and Tetrahydrocurcuminoids on the Tumor Promoter-induced Reactive Oxygen Species Generation in Leukocytes in vitro and in vivo
• 5 発がんプロモーター・インドラクタムの活性コンフォメーション(口頭発表の部)
• 発癌プロモーター・インドラクタムの活性コンフォメーション : 有機化学,天然物化学
• Coumarin-related Compounds as Plant Growth Inhibitors from Two Rutaceous Plants in Thailand
• アミロイドβ(Aβ42)の毒性コンホメーションの提唱
• P-55 βアミロイドの新しい凝集モデルに基づく神経細胞毒性発現機構(ポスター発表の部)
• 11 固体NMRならびにESRによるβアミロイド(Aβ42)の毒性コンホメーションの解析(口頭発表の部)
• 1996年度日本農芸化学会大会 (1)
• 発癌プロモーター・テレオシジンの作用機構に関する有機化学的研究
• PE-433 Reduction in Hemoglobin-Oxygen Affinity Results in the Improvement of Exercise Capacity in Mice with Chronic Heart Failure(Heart failure, basic-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• 4(A-4) CH/π相互作用に着目したプロテインキナーゼCアイソザイム選択的な薬剤の分子設計(口頭発表の部)
• ペプチド合成によるホルボールエステル受容体の機能解析
• 連載講座 「もの」が語るバイオサイエンス(6)ペプチド合成によるホルボールエステル受容体の機能解析
• 113(P-62) 発がんプロモーター・インドラクタムVのコンホメーション固定によるプロテインキナーゼCアイソザイム選択的リガンドの分子設計(ポスター発表の部)
• プロテインキナーゼCのシステインリッチドメインの化学合成, 機能解析とドラッグデザイン
• 新規光反応性フォルポールエステルを用いたプロテインキナーゼC調節領域の光アフィニティーラベリング : 有機化学・天然物化学
• ポリフェノールによるアルツハイマー病予防の可能性
• βアミロイドの毒性コンホメーション
• 26 天然発がんプロモーターの骨格を利用した抗がん剤bryostatin等価体の開発(口頭発表の部)
• 'Malignant' Conformation of Alzheimer's β Peptides (Aβ42) through Radical Formation
• P-64 ELUICIDATION OF THE 'MALIGNATNT' CONFORMATION OF β-AMYLOID WITH ITALIAN MUTATION (E22K-Aβ42) USING SOLID-STATE NMR
• P-9 FORMATION AND STABILIZATION MECHANISM OF THE β-AMYLOID RADICAL
• Structure of β-Amyloid Fibrils and Its Relevance to Their Neurotoxicity : Implications for the Pathogenesis of Alzheimer's Disease
• Synthesis and Tumor-promoting Activities of 12-Epi-phorbol-12,13-dibutyrate
• Synthesis and Biological Activities of (-)-6-n-Octyl-indolactam-V, a New Potent Analogue of the Tumor Promoter (-)-Indolactam-V
• Synthesis and Biological Activities of Indolactone-V, the Lactone Analogue of the Tumor Promoter (-)-Indolactam-V
• Photocytotoxicity of Water-soluble Fullerene Derivatives
• Inhibitory Effects of 1'-Acetoxychavicol Acetate on N-Nitrosobis(2-oxopropyl)-amine-induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters
• OE-330 Oxidative Stress Causes Heart Failure with Impaired Mitochondrial Respiration(Molecular biology, myocardium-1 (M) OE56,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• 微生物転換を用いた6位置換インドラクタムの合成研究 : 有機化学,天然物化学
• 6 プロテインキナーゼCのホルボールエステル結合部位を含むサロゲートペプチドの合成と化学的特性(口頭発表の部)
• Kurosu, a Traditional Vinegar Produced from Unpolished Rice, Suppresses Lipid Peroxidation in Vitro and in Mouse Skin
• Suppressive Effects of Natural and Synthetic Agents on Dextran Sulfate Sodium-induced Interleukin-1β Release from Murine Peritoneal Macrophages
• Antitumoral and Antimicrobial Activities of Bitter Sesquiterpene Lactones of Vernonia amygdalina, a Possible Medicinal Plant Used by Wild Chimpanzees
• Antischistosomal Activities of Sesquiterpene Lactones and Steroid Glucosides from Vernonia amygdalina, Possibly Used by Wild Chimpanzees against Parasite-related Diseases
• Ursolic Acid Enhances Cyclooxygenases and Tumor Necrosis Factor-α Expression in Mouse Skin
• Suppressive Effects of Selected Antioxidants on the Activated Leukocytes-induced Mutagenesis in the Co-culture Assay Systems
• Modifying Effects of Dietary Factors on (−)-Epigallocatechin-3-gallate-induced Pro-matrix Metalloproteinase-7 Production in HT-29 Human Colorectal Cancer Cells
• Auraptene Decreases the Activity of Matrix Metalloproteinases in Dextran Sulfate Sodium-Induced Ulcerative Colitis in ICR Mice
• Nobiletin, a Citrus Flavonoid, Down-Regulates Matrix Metalloproteinase-7 (matrilysin) Expression in HT-29 Human Colorectal Cancer Cells
• Loss of SDF-1 receptor expression during positive selection in the thymus
• Theasaponin E_1 Destroys the Salt Tolerance of Yeasts
• Physiological Characteristics of a Film-forming Strain of Zygosaccharomyces rouxii, and Its Cellular Fatty Acid Synthesis
• Possible Anti-tumor Promoting Properties of Marine Algae and In Vivo Activity of Wakame Seaweed Extract
• Biosynthesis of Abscisic Acid by the Direct Pathway via Ionylideneethane in a Fungus, Cercospora cruenta
• Actinidic Acid, a New Triterpene Phytoalexin from Unripe Kiwi Fruit
• Triterpene Phytoalexins from Strawberry Fruit
• Analysis of ^B NMR Powder Lineshape of MgB_2 in the Normal Conductive Phase(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
• フォルボールエステルのジアジリン誘導体の合成と特性 : 有機化学・天然物化学
• マウス皮膚PKC_ηの調節領域モデルペプチドの合成とその生化学的特性 : 有機化学・天然物化学
• P-38 ANALYSIS OF CH/π INTERACTION BETWEEN TUMOR PROMOTERS AND PROTEIN KINASE C C1 DOMAINS
• Binding Selectivity of Conformationally Restricted Analogues of (-)-Indolactam-V to the C1 Domains of Protein Kinase C Isozymes(Organic Chemistry)
• Selective Binding of Tumor Promoters to the Novel PKC C1B Domains
• Isolation of (-)-14-O-Malonylindolactam-V as a Possible Precursor of (-)-Indolactam-V and (-)-14-O-Acetylindolactam-V from Streptomyces blastmyceticum
• Tumor-Promoting Phorbol Esters Bind Directly to the Regulatory Domain of Diacylglycerol Kinase Gamma
• Synthesis and Characterization of Model Peptides Incorporating the Phorbol Ester-binding Domain of Protein Kinase C
• Biosynthesis of Abscisic Acid by the Non-mevalonate Pathway in Plants, and by the Mevalonate Pathway in Fungi
• Mechanism of Formation of Dehydrated Ions from Abscisic Acid and Its 1', 4'-Diol Methyl Esters in Electron Ionization Mass Spectrometry
• Biological Activities of Abscisic Acid Analogs in the Morphological Change of the Green Alga Haematococcus pluvialis
• 発がんプロモーターのnPKC C1B ドメインへの選択的結合
• New Aggregation Model of Amyloid β by the Systematic Proline Replacement
• Synthesis and Phorbol Ester Binding of the Zinc-finger Like Sequences of All Protein Kinase C Isozymes
• Identification of Toxic Conformation in Aβ42 Aggregates Using Solid-state NMR
• Changes in the Content and Biosynthesis of Phytoalexins in Banana Fruit
• Phenylphenalenone-type Phytoalexins from Unripe Bungulan Banana Fruit
• Synthesis and Biological Activities of 8'-Methylene- and 8'-Methylidyneabscisic Acids
• Synthesis, Biological Activity, and Metabolism of 8', 8', 8'-Trideuteroabscisic Acid
• Association between frequency of amino acid changes in core region of hepatitis B virus (HBV) and the presence of precore mutation in Japanese HBV carriers
• Silymarin Attenuated the Amyloid β Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer's Disease Mouse Model
• The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide : The emerging role in the pathogenesis of Alzheimer's disease
• Verification of the Intermolecular Parallel β-Sheet in E22K-Aβ42 Aggregates by Solid-State NMR Using Rotational Resonance : Implications for the Supramolecular Arrangement of the Toxic Conformer of Aβ42
• CH/π相互作用を利用した薬剤開発(最前線,ポストゲノム時代の有機化学)
• Silymarin Attenuated the Amyloid β Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer’s Disease Mouse Model
• Surgical Resection for Hepatocellular Carcinoma with Metastasis to the Gallbladder : Report of a Case
• プロテインキナーゼ C 機能ドメインの化学合成
• プロテインキナーゼCの2つのzinc fingerモチーフの機能と役割
• Teleocidin類の構造活性相関と蛍光標識化
• プロテインキナーゼCのホルボールエステル結合部位の光アフィニティーラベリングによる構造解析
• プロテインキナーゼCのホルボールエステル結合部位の合成と化学的特性
• Synthesis and Biological Evaluation of the 12,12-Dimethyl Derivative of Aplog-1, an Anti-Proliferative Analog of Tumor-Promoting Aplysiatoxin
• 11B Nuclear Magnetic Resonance Study on Existence of Boron–Hydrogen Complex in Boron-Doped Diamond

もっと見る 閉じる

スポンサーリンク