In Vitro Absorption and Metabolism of Nobiletin, a Chemopreventive Polymethoxyflavonoid in Citrus Fruits

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概要

• 論文の詳細を見る

• The polymethoxyflavonoid (PMF), nobiletin (NOB), specifically occurs in citrus fruits, and is currently believed to be a promising anti-inflammatory and antitumor promoting agent. In the present study, we investigated the in vitro absorption and metabolism of NOB and compared them with those of the polyhydroxyflavonoid (PHF), luteolin (LT). NOB preferentially accumulated in a differentiated Caco-2 cell monolayer, which is a model for small intestinal epithelial cells, while LT did not. Treatment of NOB with a rat liver S-9 mixture led to the formation of 3'-demethyl-NOB, while that of LT did not. We thus suggest that PMFs including NOB have properties distinct from those of general flavonoids for absorption and metabolism in vitro.

• 社団法人日本農芸化学会の論文
• 2001-01-23

著者

• MURAKAMI Akira

  Department of Ophthalmology, Juntendo University School of Medicine

• MURAKAMI Akira

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• OHIGASHI Hajime

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• Murakami A

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• KOSHIMIZU Koichi

  Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Kinki Un

• KUWAHARA Shigeru

  Research and Development Division, Wakayama Agricultural Processing Research Corporation

• TAKAHASHI Yasuo

  Research and Development Division, Wakayama Agricultural Processing Research Corporation

• ITO Chihiro

  Faculty of Pharmacy, Meijo University

• FURUKAWA Hiroshi

  Faculty of Pharmacy, Meijo University

• JU-ICHI Motoharu

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• Ohigashi H

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• Ju‐ichi M

  Mukogawa Women's Univ. Hyogo Jpn

• Ju-ichi Motoharu

  Faculty Of Pharmaceutical Science Mukogawa Women's University

• Ju-ichi Motoharu

  Fac. Of Pharmaceutical Sciences Mukogawa Women's Univ.

• Ju-ichi Motoharu

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Koshimizu K

  Department Of Biotechnological Science Faculty Of Biology-oriented Science And Technology Kinki Univ

• Koshimizu Koichi

  京都大学 農研究

• Koshimizu Kouichi

  岐阜大学 第1病理

• 井藤 千裕

  名城大学薬学部薬化学

• Ju‐ichi M

  Faculty Of Pharmaceutical Science Mukogawa Women's University

• Ohigashi Hajime

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Kasahara Ken-ichiro

  Division Of Pathology National Institute Of Health Sciences

• Motoharu J

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Furukawa H

  Faculty Of Pharmacy Meijo University

• Kuwahara Shigeru

  Research And Development Division Wakayama Agricultural Processing Research Corporation

• Ito Chihiro

  Faculty Of Pharmacy Meijo University

• Koshimizu Koichi

  Department Of Biotechnological Science Faculty Of Biology-oriented Science And Technology Kinki Univ

• Murakami Akiko

  Department Of Food And Nutrition Kinki University

• Furukawa Hiroshi

  Faculty Of Pharmacy Meijo University

• Takemura Y

  Mukogawa Women's Univ. Hyogo Jpn

• Takahashi Y

  Graduate School Of Engineering Oita University

• Ohigashi Hajime

  Div. Of Food Sci. And Biotechnology Graduate School Of Agriculture Kyoto Univ.

• Murakami Akira

  Department Of Biomolecular Engineering Kyoto Institute Of Technology

• Murakami A

  Department Of Food And Nutrition Kinki University

• Murakami Akira

  Department Of Biomolecular Engineering Graduate School Of Science And Technology Kyoto Institute Of

• Murakami Akira

  Department Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• Furukawa Hiroshi

  Faculty Of Computer Science And Systems Engineering Kyushu Institute Of Technology

• Murakami Akira

  Departmemt of Cardiology, Surugadai Nihon University Hospital

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