An Avocado Constituent, Persenone A, Suppresses Expression of Inducible Forms of Nitric Oxide Synthase and Cyclooxygenase in Macrophages, and Hydrogen Peroxide Generation in Mouse Skin

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概要

• 論文の詳細を見る

• We investigated the suppressive effects of an avocado constituent, persenone A, on lipopolysaccharide-and interferon-γ-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) in a mouse macrophage cell line RAW 264.7. Persenone A at concentration of 20μM almost completely suppressed both iNOS and COX-2 protein expression. In mouse skin, double treatments with persenone A (810 nmol) significantly suppressed double 12-O-tetradecanoylphorbol-13-acetate (TPA, 8.1 nmol) application-induced hydrogen peroxide (H_2O_2) generation. Treatment with persenone A before the second TPA treatment was sufficient to inhibit H_2O_2 generation, while the first treatment was not. This study thus suggests that persenone A is a possible agent to prevent inflammation-associated diseases including cancer.

• 社団法人日本農芸化学会の論文
• 2000-11-23

著者

• MURAKAMI Akira

  Department of Ophthalmology, Juntendo University School of Medicine

• MURAKAMI Akira

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• OHIGASHI Hajime

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• Takahashi Daisuke

  Department of Materials Science and Technology, Niigata University

• Nakamura Yoshimasa

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Murakami A

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• KIM OeKyung

  Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University

• TORIKAI Koji

  Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University

• KIM HaWon

  Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University

• Nakamura Y

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Ohigashi H

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• Kim Hawon

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Kim Oekyung

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Torikai Koji

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Ohigashi Hajime

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Takahashi D

  Waseda Univ. Tokyo

• Murakami Akiko

  Department Of Food And Nutrition Kinki University

• Takahashi Daisuke

  Department Of Applied Chemistry Faculty Of Science And Technology Keio University

• Ohigashi Hajime

  Div. Of Food Sci. And Biotechnology Graduate School Of Agriculture Kyoto Univ.

• Murakami Akira

  Department Of Biomolecular Engineering Kyoto Institute Of Technology

• Murakami A

  Department Of Food And Nutrition Kinki University

• Murakami Akira

  Department Of Biomolecular Engineering Graduate School Of Science And Technology Kyoto Institute Of

• Takahashi Daisuke

  Department Of Applied Mathematics And Informaties Faculty Of Science And Technology Ryukoku Universi

• Murakami Akira

  Department Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• Kim Oe

  Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University

• Takahashi Daisuke

  Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Kinki University

• Murakami Akira

  Departmemt of Cardiology, Surugadai Nihon University Hospital

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