Chalcone Tetramers, Lophirachalcone and Alatachalcone, from Lophira alata as Possible Anti-tumor Promoters

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概要

• 論文の詳細を見る

• Two chalcone tetramers were isolated as inhibitors of Epstein-Barr virus (EBV)-activation induced by a tumor promoter, teleocidin B-4,from a medicinal plant in tropical west Africa, Lophira alata (Ochnaceae). One of them was identified as lophirachalcone. The other, named alatachalcone, was new, and the structure was determined by spectral properties. Both compounds also showed potent inhibitory activities against teleocidin B-4-induced inflammation on mouse ear. In an initiation-promotion experiment on mouse skin, alatachalcone (16nmol) significantly inhibited tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate (TPA, 1.6nmol).

• 社団法人日本農芸化学会の論文
• 1992-05-23

著者

• MURAKAMI Akira

  Department of Ophthalmology, Juntendo University School of Medicine

• HIROTA Mitsuru

  Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University

• MURAKAMI Akira

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• Murakami A

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• KOSHIMIZU Koichi

  Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Kinki Un

• OHIGASHI Hajime

  Department of Food Science and Technology, Faculty of Agriversity, Kyoto University

• Koshimizu Koichi

  京都大学 農研究

• Koshimizu Kouichi

  岐阜大学 第1病理

• Hirota Mitsuru

  Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University

• Hirota Mitsuru

  Department Of Bioscience And Technology Faculty Of Agriculture Shinsyu University

• Ohigashi Hajime

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Kasahara Ken-ichiro

  Division Of Pathology National Institute Of Health Sciences

• Koshimizu Koichi

  Department Of Biotechnological Science Faculty Of Biology-oriented Science And Technology Kinki Univ

• Irie Ryozo

  Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University

• Irie Ryozo

  Department Of Bioscience And Technology Faculty Of Agriculture Shinsyu University

• Irie Ryozo

  Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University

• TAKEDA Naohito

  Faculty of Pharmacy, Meijo University

• TATEMATSU Akira

  Faculty of Pharmacy, Meijo University

• Tatematsu A

  Faculty Of Pharmacy Meijo University

• Takeda Natsuko

  Faculty Of Pharmacy Meijo University

• Takeda Naohito

  Faculty Of Pharmacy Meijo University

• Ohigashi Hajime

  Div. Of Food Sci. And Biotechnology Graduate School Of Agriculture Kyoto Univ.

• Tatematsu Akira

  Faculty Of Pharmacy Meijo University

• Tanaka Shizuko

  Agricultural Chemicals Research Laboratory Sumitomo Chemical Co. Ltd.

• TANAKA Shizuko

  Department of Food Science and Technology, Faculty of Agriculture, Kyoto University

• Murakami Akira

  Department Of Biomolecular Engineering Kyoto Institute Of Technology

• Murakami Akira

  Department Of Biomolecular Engineering Graduate School Of Science And Technology Kyoto Institute Of

• Takeda N

  Meijo Univ. Nagoya Jpn

• Ohigashi Hajime

  Department Of Bioscience Faculty Of Biotechnology Fukui Prefectural University

• Murakami Akira

  Departmemt of Cardiology, Surugadai Nihon University Hospital

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