Suppressive Effects of Selected Antioxidants on the Activated Leukocytes-induced Mutagenesis in the Co-culture Assay Systems
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概要
- 論文の詳細を見る
We recently established a novel co-culture assay system using activated inflammatory cells and AS52 Chinese hamster ovary cells, and demonstrated that reactive oxygen and nitrogen species (RONS) generated from activated inflammatory leukocytes induce mutations in the gpt recorder gene in AS52 cells. In this study, we examined the inhibitory effects of 19 agents with antioxidative properties on RONS generation in cultured inflammatory cells and on mutagenesis in AS52 cells co-cultured with activated inflammatory cells. The results demonstrate that there is a linear correlation between the ability of these agents to suppress RONS production in activated inflammatory cells and to inhibit mutation in AS52 cells.
- 社団法人 日本農芸化学会の論文
- 2004-01-23
著者
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MURAKAMI Akira
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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OHIGASHI Hajime
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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Ohigashi Hajime
Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University
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KIM Ha
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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WILLIAMS Marshall
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University
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Murakami Akira
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Kim Ha
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Williams Marshall
Department Of Molecular Virology Immunology And Medical Genetics The Ohio State University
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