Synthesis and Biological Activities of (-)-6-n-Octyl-indolactam-V, a New Potent Analogue of the Tumor Promoter (-)-Indolactam-V
スポンサーリンク
概要
- 論文の詳細を見る
(-)-Indolactam-V (1) without a hydrophobic chain at positions 6 and 7 of the indole ring is a weak tumor promoter compared with teleocidin Bs. To investigate the effects of the hydrophobic substituent at position 6 of teleocidin Bs, we synthesized (-)-6-n-octyl-indolactam-V (2) by a palladium-catalyzed coupling reaction from (-)-6-bromo-indolactam-V (7) which had been obtained by microbial conversion with Streptoverticillium blastmyceticum NA34-17 as the key step. (-)-7-n-Octyl-indolactam-V (3) with potent biological activities comparable to those of teleocidin Bs was similarly synthesized from (-)-7-bromoindolactam-V as a positive control. Compound 2 showed similar biological activities to those of 3,indicating that the effect of the hydrophobic substituent at position 6 of 1 was identical to that at position 7.
- 社団法人日本農芸化学会の論文
- 1998-08-23
著者
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OHIGASHI Hajime
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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Ohigashi H
Department Of Surgery Osaka Medical Center For Cancer And Cardiovascular Diseases
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Ohigashi Hiroaki
Department Of Surgery The Center For Adult Diseases
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入江 一浩
京都大学農学部
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入江 一浩
京都大学 食品工学
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入江 一浩
京都大学 農
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入江 一浩
京都大学大学院農学研究科食品生物科学
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Nakamura Yoshimasa
Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University
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Nakamura Y
Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University
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Ohigashi H
Graduate School Of Agriculture Kyoto University
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Ohigashi H
Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University
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HAYASHI Hideo
Deparment of Applied Biological Chemistry, College of Agriculture, Osaka Prefecture University
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Nakagawa Y
Graduate School Of Agriculture Kyoto University
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Nakagawa Yu
Graduate School Of Agriculture Kyoto University
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Hayashi H
Osaka Prefecture Univ. Osaka Jpn
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Nakagawa Yasue
Department Of Food Faculty Of Home Economics Jissen Women's University
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Ohigashi Hajime
Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University
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IRIE KAZUHIRO
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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NAKAGAWA Yu
Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University
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Irie Kazuhiro
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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入江 一浩
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Nakagawa Yu
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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