Nobiletin, a Citrus Flavonoid, Down-Regulates Matrix Metalloproteinase-7 (matrilysin) Expression in HT-29 Human Colorectal Cancer Cells
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概要
- 論文の詳細を見る
Overexpression of matrix metalloproteinases (MMPs) is associated with cancer metastasis. We assessed mRNA expression of MMPs in six human colorectal cancer cell lines and found a considerable level of MMP-7 expression in HT-29 cells. Next, we searched for natural and synthetic compounds that cause a reduction in the production of proMMP-7 protein, and found that nobiletin (NOB), quercetin, valeryl salicylate, and sulindac sulfone demonstrated marked inhibition. Importantly, NOB attenuated proMMP-7 protein and its mRNA expression both concentration- and time-dependently via a reduction of activator protein-1 (AP-1) DNA binding activity, suggesting it as a promising agent for suppression of cancer cell invasion and metastasis through MMP-7 gene repression.
- 社団法人 日本農芸化学会の論文
- 2005-02-23
著者
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MURAKAMI Akira
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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OHIGASHI Hajime
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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Ohigashi Hajime
Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University
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KAWABATA Kyuichi
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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Murakami Akira
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Ohigashi Hajime
Div. Of Food Sci. And Biotechnology Graduate School Of Agriculture Kyoto Univ.
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Kawabata Kyuichi
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Murakami Akira
Department Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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