Zerumbone Suppresses Phorbol Ester-Induced Expression of Multiple Scavenger Receptor Genes in THP-1 Human Monocytic Cells
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概要
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Unregulated uptake of oxidized low-density lipoproteins (ox-LDL) via macrophage scavenger receptors (SRs), such as lectin-like ox-LDL receptor-1 (LOX-1), is a key event in atherosclerosis. In the present study, we used differentiated Caco-2 cells as a model of the human small intestine to evaluate the suppressive effects of 16 traditional food items selected from Okinawa on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced LOX-1 mRNA expression in THP-1 human monocyte-like cells. Three Zingiberaceae plants, Curcuma aromatica Salisbury, Curcuma longa L., and Zingiber zerumbet Smith, markedly suppressed that expression. When added to the apical sides of Caco-2 monolayers, zerumbone, a sesquiterpene from Z. zerumbet Smith, was found to permeate into the basolateral medium as an intact structure in a time-dependent manner. α-Humulene, a structural analog of zerumbone lacking the α,β-unsaturated carbonyl group, did not suppress LOX-1 mRNA expression, indicating that its electrophilic moiety might play pivotal roles in its activities. Further, zerumbone attenuated the expression of SR-A, SR-PSOX, and CD36, but not that of CD68 or CLA-1, leading to a blockade of DiI-acLDL uptake, while it also inhibited the transcriptional activities of activator protein-1 and nuclear factor-κB. Together, our results indicate that zerumbone is a potential phytochemical for regulating atherosclerosis with reasonable action mechanisms.
- 2007-04-23
著者
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Murakami Akira
Div. Of Food Sci. And Biotechnology Graduate School Of Agriculture Kyoto Univ.
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Ohigashi Hajime
Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University
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Murakami Akira
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Kaneko Yuki
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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EGUCHI Ai
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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Eguchi Ai
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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