Combinatorial Effects of Nonsteroidal Anti-inflammatory Drugs and Food Constituents on Production of Prostaglandin E_2 and Tumor Necrosis Factor-α in RAW264.7 Murine Macrophages(Food & Nutrition Science)

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概要

• 論文の詳細を見る

• Combinatorial chemopreventive strategies, in contrast to those with individual agents, show potential in terms of potentially lower toxicity and higher efficacy.In this study, we combined several agents and examined their suppressive effects on the combined lipopolysaccharide (LPS) - and interferon (IFN) -γ-induced formation of proinflammatory mediators, including prostaglandin (PG) E_2 and tumor necrosis factor (TNF) -α, in RAW264.7 murine macrophages. The combinatorial effects of indomethacin/genistein (GEN) and aspirin/GEN were found to be synergistic for PGE_2 suppression, while the nimesulide/GEN combination was antagonistic. Further, while (-) -epigallocatechin gallate (EGCG) alone increased LPS/IFM-γ-induced production of PGE_2 and TNF-α as well as cyclooxygenase-2 expression, the EGCG/GEN combination markedly suppressed these parameters. Our results suggest that certain chemopreventive agents act complexly and that, when used in combination, they affect the intracellular signaling pathways of the paired agents to exert additive, synergistic, or antagonistic effects.

• 社団法人日本農芸化学会の論文
• 2003-05-23

著者

• MURAKAMI Akira

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• OHIGASHI Hajime

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• Takahashi Daisuke

  Department of Materials Science and Technology, Niigata University

• Murakami A

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• HAGIHARA Kazuma

  Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Kinki Un

• KOSHIMIZU Koichi

  Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Kinki Un

• Ohigashi H

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• Koshimizu K

  Department Of Biotechnological Science Faculty Of Biology-oriented Science And Technology Kinki Univ

• Koshimizu Koichi

  京都大学 農研究

• Koshimizu Kouichi

  岐阜大学 第1病理

• Hagihara Kazuma

  京都大学 農研究

• Hagihara Kazuma

  Department Of Biotechnological Science Faculty Of Biology-oriented Science And Technology Kinki Univ

• Ohigashi Hajime

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Kasahara Ken-ichiro

  Division Of Pathology National Institute Of Health Sciences

• Takahashi D

  Waseda Univ. Tokyo

• Koshimizu Koichi

  Department Of Biotechnological Science Faculty Of Biology-oriented Science And Technology Kinki Univ

• Murakami Akiko

  Department Of Food And Nutrition Kinki University

• Murakami Akira

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• Takahashi Daisuke

  Department Of Applied Chemistry Faculty Of Science And Technology Keio University

• Ohigashi Hajime

  Div. Of Food Sci. And Biotechnology Graduate School Of Agriculture Kyoto Univ.

• Murakami A

  Department Of Food And Nutrition Kinki University

• Takahashi Daisuke

  Department Of Applied Mathematics And Informaties Faculty Of Science And Technology Ryukoku Universi

• Murakami Akira

  Department Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• Takahashi Daisuke

  Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Kinki University

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