Screening for the In Vitro Anti-tumor-promoting Activities of Edible Plants from Malaysia

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概要

• 論文の詳細を見る

• A total of 114 methanol extracts from 42 plant families of edible Malaysian plants were screened for their inhibitory activities toward tumor promoter 12-O-hex-adecanoylphorbol-13-acetate (HPA)-induced Epstein-Barr virus (EBV) activation in Raji cells. By testing at a concentration of 200 μg/ml, 74% of the 114 extracts inhibited EBV activation by 30% or more. This rate is comparable to those observed in the previous tests on edible Thai (60%) and Indonesian (71%) plants, and, importantly, much higher than that (26%) observed for Japanese edible plants. Approximately half of the Malaysian plants did not taxonomically overlap those from the other three countries, suggesting that Malaysian plants, as well as Thai and Indonesian plants, are an exclusive source of effective chemopreventive agents. Further dilution experiments indicated an extract from the leaves of Piper betle L. (Piperaceae) to be one of the most promising species. The high potential of edible Southeast Asian plants for cancer chemoprevention is collectively discussed.

• 社団法人日本農芸化学会の論文
• 2000-01-23

著者

• MURAKAMI Akira

  Department of Ophthalmology, Juntendo University School of Medicine

• MURAKAMI Akira

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• OHIGASHI Hajime

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• Murakami A

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• KOSHIMIZU Koichi

  Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Kinki Un

• ALI AbdulManaf

  Department of Biotechnology, Faculty of Food Science and Technology, Universiti Putra Malaysia

• MAT-SALLEH Kamaruddin

  Department of Botany, Faculty of Life Sciences, Universiti Kebangsaan Malaysia

• Ohigashi H

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• Koshimizu K

  Department Of Biotechnological Science Faculty Of Biology-oriented Science And Technology Kinki Univ

• Koshimizu Koichi

  京都大学 農研究

• Mat-salleh Kamaruddin

  Department Of Botany Faculty Of Life Sciences Universiti Kebangsaan Malaysia

• Mat-salleh Kamaruddin

  Department Of Botany Faculty Of Life Sciences University Kebangsaan Malaysia

• Koshimizu Kouichi

  岐阜大学 第1病理

• Ali Abdulmanaf

  Department Of Biotechnology Faculty Of Food Science And Technology Universiti Putra Malaysia

• Ohigashi Hajime

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Kasahara Ken-ichiro

  Division Of Pathology National Institute Of Health Sciences

• Koshimizu Koichi

  Department Of Biotechnological Science Faculty Of Biology-oriented Science And Technology Kinki Univ

• Murakami Akiko

  Department Of Food And Nutrition Kinki University

• Ohigashi Hajime

  Div. Of Food Sci. And Biotechnology Graduate School Of Agriculture Kyoto Univ.

• ALI Abdul

  Department of Biotechnology, Faculty of Food Science and Biotechnology, Universiti Putra Malaysia

• Murakami Akira

  Department Of Biomolecular Engineering Kyoto Institute Of Technology

• Murakami A

  Department Of Food And Nutrition Kinki University

• Murakami Akira

  Department Of Biomolecular Engineering Graduate School Of Science And Technology Kyoto Institute Of

• Murakami Akira

  Department Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• Murakami Akira

  Departmemt of Cardiology, Surugadai Nihon University Hospital

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