Auraptene Decreases the Activity of Matrix Metalloproteinases in Dextran Sulfate Sodium-Induced Ulcerative Colitis in ICR Mice
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概要
- 論文の詳細を見る
Previously we reported that auraptene was a potent suppressant for matrix metalloproteinase (MMP)-7 expression in HT-29 human colon cancer cells. In the present study, we examined the effects of auraptene on MMP-2, -7, and -9 expression in colonic mucosa from dextran sulfate sodium (DSS)-induced ulcerative colitis mice. Auraptene remarkably suppressed the DSS-induced gelatinolytic activity of MMP-7 as well as the expression of MMP-2 and -9, suggesting that it might be useful in anti-metastatic therapies via the targeting of MMPs.
- 社団法人 日本農芸化学会の論文
- 2006-12-23
著者
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MURAKAMI Akira
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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OHIGASHI Hajime
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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Ohigashi Hajime
Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University
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KAWABATA Kyuichi
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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Murakami Akira
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Ohigashi Hajime
Div. Of Food Sci. And Biotechnology Graduate School Of Agriculture Kyoto Univ.
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Kawabata Kyuichi
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Murakami Akira
Department Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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