Anti-tumor Promoting Activity of Bufadienolides from Kalanchoe pinnata and K.daigremontiana×tubiflora

スポンサーリンク

概要

• 論文の詳細を見る

• Five bufadienolides (1-5) isolated from the leaves of Kalanchoe pinnata and K.daigremontiana×tubiflora (Crassulaceae) were examined for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate. All bufadienolides showed inhibitory activity, and bryophyllin A (1) exhibited the most marked inhibition (IC_<50>=0.4 μm) among the tested compounds. Bryophyllin C (2), a reduction analogue of 1,and bersaldegenin-3-acetate (3) lacking the orthoacetate moiety were less active. These results strongly suggest that bufadienolides are potential cancer chemopreventive agents.

• 社団法人日本農芸化学会の論文
• 2001-04-23

著者

• MURAKAMI Akira

  Department of Ophthalmology, Juntendo University School of Medicine

• MURAKAMI Akira

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• OHIGASHI Hajime

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• Fujita Tomoyuki

  Division Of Cardiovascular Surgery Department Of Surgery Osaka University Graduate School Of Medicin

• Murakami A

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• KOSHIMIZU Koichi

  Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Kinki Un

• SUPRATMAN Unang

  Division of Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, Osaka Pr

• AKIYAMA Kohki

  Division of Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, Osaka Pr

• HAYASHI Hideo

  Division of Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, Osaka Pr

• SAKAI Hirofumi

  Department of Biotechnological Science, Faculty of Biology-oriented Science and Technology, Kinki Un

• Ohigashi H

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• Supratman Unang

  Division Of Applied Biological Chemistry Graduate School Of Agriculture And Life Sciences Osaka Pref

• Supratman Unang

  Department Of Applied Biological Chemistry College Of Agriculture Osaka Prefecture University

• Akiyama Kohki

  Division Of Applied Biological Chemistry Graduate School Of Agriculture And Biological Sciences Osak

• Koshimizu K

  Department Of Biotechnological Science Faculty Of Biology-oriented Science And Technology Kinki Univ

• Koshimizu Koichi

  京都大学 農研究

• Koshimizu Kouichi

  岐阜大学 第1病理

• Akiyama K

  Osaka Prefecture Univ. Osaka Jpn

• Sakai Hirofumi

  Department Of Biotechnological Science Faculty Of Biology-oriented Science And Technology Kinki Univ

• Hayashi H

  Osaka Prefecture Univ. Osaka Jpn

• Furuki T

  Natural History Museum & Institute

• Ohigashi Hajime

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Kasahara Ken-ichiro

  Division Of Pathology National Institute Of Health Sciences

• Koshimizu Koichi

  Department Of Biotechnological Science Faculty Of Biology-oriented Science And Technology Kinki Univ

• Murakami Akiko

  Department Of Food And Nutrition Kinki University

• Tomoyuki Fujita

  Division Of Applied Biological Chemistry Graduate School Of Agriculture And Biological Sciences Osak

• Sakai Hirofumi

  Department Of Biochemistry Faculty Of Veterinary Medicine Hokkaido University

• Kondo A

  Shiga Agricultural Experiment Station Shiga Jpn

• Ohigashi Hajime

  Div. Of Food Sci. And Biotechnology Graduate School Of Agriculture Kyoto Univ.

• Murakami Akira

  Department Of Biomolecular Engineering Kyoto Institute Of Technology

• Murakami A

  Department Of Food And Nutrition Kinki University

• Fujita Tomoyuki

  Division Of Applied Biological Chemistry Graduate School Of Agriculture And Biological Sciences Osak

• Murakami Akira

  Department Of Biomolecular Engineering Graduate School Of Science And Technology Kyoto Institute Of

• Hayashi Hideo

  Division Of Applied Biological Chemistry Graduate School Of Agriculture And Biological Sciences Osak

• Murakami Akira

  Department Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• Murakami Akira

  Departmemt of Cardiology, Surugadai Nihon University Hospital

関連論文

• A Novel Mutation (967-970+2)delAAAGGT in the Choroideremia Gene Found in a Japanese Family and Related Clinical Findings
• Lack of Enhancing Effect of Lauric Acid on the Development of Aberrant Crypt Foci in Male ICR Mice Treated with Azoxymethane and Dextran Sodium Sulfate
• ROLE OF RENAL SYMPATHETIC NERVE IN DEVELOPMENT OF HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RAT (SHR) : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
• THE ROLE OF THE AUTONOMIC NERVOUS ACTIVITY IN ESSENTIAL HYOERTENSION : Cardiac Surgery II, Hemodialysis, Hypertension II : IInd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
• STUDIES ON HYPERTENSION: EFFECTS OF SALT ADMINISTRATION ON HUMORAL FACTORS AND HISTOLOGICAL CHANGES IN SHR : IInd Auditorium
• Combinatorial Effects of Nonsteroidal Anti-inflammatory Drugs and Food Constituents on Production of Prostaglandin E_2 and Tumor Necrosis Factor-α in RAW264.7 Murine Macrophages(Food & Nutrition Science)
• Suppression of N-Nitrosomethylbenzylamine-induced Rat Esophageal Tumorigenesis by Dietary Feeding of 1'-Acetoxychavicol Acetate.
• Anti-tumor Promoting Activity of Bufadienolides from Kalanchoe pinnata and K.daigremontiana×tubiflora
• In Vitro Absorption and Metabolism of Nobiletin, a Chemopreventive Polymethoxyflavonoid in Citrus Fruits
• An Avocado Constituent, Persenone A, Suppresses Expression of Inducible Forms of Nitric Oxide Synthase and Cyclooxygenase in Macrophages, and Hydrogen Peroxide Generation in Mouse Skin
• Inhibition by (-)-Persenone A-related Compounds of Nitric Oxide and Superoxide Generation from Inflammatory Leukocytes
• Immunomodulatory Action of Citrus Auraptene ton Macrophage Functions and Cytokine Production of Lymphocytes in Female BALB/c Mice.
• Suppression of N-Nitrosomethylbenzylamine-induced Rat Esophageal Tumorigenesis by Dietary Feeding of 1'-Acetoxychavicol Acetate
• Screening for the In Vitro Anti-tumor-promoting Activities of Edible Plants from Malaysia
• Identification of Zerumbone in Zingiber zerumbet Smith as a Potent Inhibitor of 12-O-Tetradecanoylphorbol-13-acetate-induced Epstein-Barr Virus Activation
• Citrus Auraptene Exerts Dose-dependent Chemopreventive Activity in Rat Large Bowel Tumorigenesis : The Inhibition Correlates with Suppression of Cell Proliferation and Lipid Peroxidation and with Induction of Phase II Drug-me
• Citrus Auraptene Inhibits Chemically Induced Colonic Aberrant Crypt Foci in Male F344 Rats.
• Chemoprevention of Azoxymethane-induced Rat Colon Carcinogenesis by a Xanthine Oxidase Inhibitor, 1'-Acetoxychavicol Acetate.
• A Xanthine Oxiedase Inhibitor 1'-Acetoxychavicol Acetate Inhibits Azoxymethane-induced Colonic Aberrant Crypt Foci in Rats.
• Inhibitory Effects of Curcumin and Tetrahydrocurcuminoids on the Tumor Promoter-induced Reactive Oxygen Species Generation in Leukocytes in vitro and in vivo
• Chemoprevention of Azoxymethane-induced Rat Colon Carcinogenesis by a Xanthine Oxidase Inhibitor, 1'-Acetoxychavicol Acetate
• Chemopreventive Effect of a Xanthine Oxidase Inhibitor, l'-Acetoxychavicol Acetate, on Rat Oral Carcinogenesis.
• Auraptene, a Citrus Coumarin, Inhibits 12-O-Tetradecanoylphorbol-13-acetate-induced Tumor Promotion in ICR Mouse Skin, Possibly through Suppression of Superoxide Generation in Leukocytes
• Identitication of Pheophorbide a and Its Related Compounds as Possible Anti-tumor Promoters in the Leaves of Neptunia oleracea
• Coumarin-related Compounds as Plant Growth Inhibitors from Two Rutaceous Plants in Thailand
• Chemopreventive Effect of a Xanthine Oxidase Inhibitor, 1'-Acetoxychavicol Acetate, on Rat Oral Carcinogenesis
• Successful Treatment of Cardiogenic Shock Caused by Humoral Cardiac Allograft Rejection
• Stem Cell Factor in the Tear Fluid of Vernal Keratoconjunctivitis Patients
• Mast Cells in Pterygium : Number and Phenotype
• Structure of β-Amyloid Fibrils and Its Relevance to Their Neurotoxicity : Implications for the Pathogenesis of Alzheimer's Disease
• Synthesis and Tumor-promoting Activities of 12-Epi-phorbol-12,13-dibutyrate
• Synthesis and Biological Activities of (-)-6-n-Octyl-indolactam-V, a New Potent Analogue of the Tumor Promoter (-)-Indolactam-V
• Synthesis and Biological Activities of Indolactone-V, the Lactone Analogue of the Tumor Promoter (-)-Indolactam-V
• Inhibitory Effects of 1'-Acetoxychavicol Acetate on N-Nitrosobis(2-oxopropyl)-amine-induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters
• Experimantal Study of Inclusive Reaction ^C(γ,π^-) at 44.2°
• Kurosu, a Traditional Vinegar Produced from Unpolished Rice, Suppresses Lipid Peroxidation in Vitro and in Mouse Skin
• Possible Anti-tumor Promoting Properties of Edible Plants from Thailand, and Identification of an Active Constituent, Cardamonin, of Boesenbergia pandurata
• Suppressive Effects of Natural and Synthetic Agents on Dextran Sulfate Sodium-induced Interleukin-1β Release from Murine Peritoneal Macrophages
• A Novel Mutation in the Cornea-Specific Keratin 12 Gene in Meesmann Corneal Dystrophy
• Novel Mutation (V505D) of the TGFBI Gene Found in A Chinese Family with Lattice Corneal Dystrophy, Type I
• Mutations in the Membrane Component, Chromosome 1, Surface Marker 1 (M1S1) Gene in Gelatinous Drop-like Corneal Dystrophy
• Analysis of COL8A2 Gene Mutation in Japanese Patients with Fuchs' Endothelial Dystrophy and Posterior Polymorphous Dystrophy
• Mutation Analysis of the TGFBI Gene in Vietnamese with Granular and Avellino Corneal Dystrophy
• OPA1 Gene Mutations in Japanese Patients with Bilateral Optic Atrophy Unassociated with Mitochondrial DNA Mutations at nt 11778, 3460, and 14484
• Multiplex Polymerase Chain Reaction for Detection of Herpes Simplex Virus Type 1, Type 2, Cytomegalovirus, and Varicella-Zoster Virus in Ocular Viral Infections
• A Novel Mutation of the TGFBI Gene Found in a Vietnamese Family with Atypical Granular Corneal Dystrophy
• Transferrin-Polyethylenimine Conjugate, FuGENE6 and TransIT-LT as Nonviral Vectors for Gene Transfer to the Corneal Endothelium
• MISSENSE MUTATION OF RHODOPSIN GENE CODON 15 FOUND IN JAPANESE AUTOSOMAL DOMINANT RETINITIS PIGMENTOSA
• A Case of Oculodentodigital Dysplasia Syndrome with Novel GJA1 Gene Mutation
• Long-term Follow-up of Two Sisters with Leber's Hereditary Optic Neuropathy
• Expression and Distribution of Junctional Adhesion Molecule-1 in the Human Cornea
• Preparation and properties of ProNectin F-coated biodegradable hollow fibers
• Effect of Cation Content of Polycation-type Gene Carriers on in vitro Gene Transfer
• Expression of Stem Cell Factor in Pterygium
• Ursolic Acid Enhances Cyclooxygenases and Tumor Necrosis Factor-α Expression in Mouse Skin
• Suppressive Effects of Selected Antioxidants on the Activated Leukocytes-induced Mutagenesis in the Co-culture Assay Systems
• Modifying Effects of Dietary Factors on (−)-Epigallocatechin-3-gallate-induced Pro-matrix Metalloproteinase-7 Production in HT-29 Human Colorectal Cancer Cells
• Auraptene Decreases the Activity of Matrix Metalloproteinases in Dextran Sulfate Sodium-Induced Ulcerative Colitis in ICR Mice
• Nobiletin, a Citrus Flavonoid, Down-Regulates Matrix Metalloproteinase-7 (matrilysin) Expression in HT-29 Human Colorectal Cancer Cells
• Theasaponin E_1 Destroys the Salt Tolerance of Yeasts
• Biosynthesis of Abscisic Acid by the Direct Pathway via Ionylideneethane in a Fungus, Cercospora cruenta
• Actinidic Acid, a New Triterpene Phytoalexin from Unripe Kiwi Fruit
• Triterpene Phytoalexins from Strawberry Fruit
• 1'-Acetoxychavicol Acetate as a Potent Inhibitor of Tumor Promoter-induced Epstein-Barr Virus Activation from Languas galanga, a Traditional Thai Condiment
• Monitoring Cellular Events in Living Mast Cells Stimulated with an Extremely Small Amount of Fluid on a Microchip
• Binding Selectivity of Conformationally Restricted Analogues of (-)-Indolactam-V to the C1 Domains of Protein Kinase C Isozymes(Organic Chemistry)
• Isolation of (-)-14-O-Malonylindolactam-V as a Possible Precursor of (-)-Indolactam-V and (-)-14-O-Acetylindolactam-V from Streptomyces blastmyceticum
• Tumor-Promoting Phorbol Esters Bind Directly to the Regulatory Domain of Diacylglycerol Kinase Gamma
• Biosynthesis of Abscisic Acid by the Non-mevalonate Pathway in Plants, and by the Mevalonate Pathway in Fungi
• Mechanism of Formation of Dehydrated Ions from Abscisic Acid and Its 1', 4'-Diol Methyl Esters in Electron Ionization Mass Spectrometry
• Biological Activities of Abscisic Acid Analogs in the Morphological Change of the Green Alga Haematococcus pluvialis
• Anti-tumor Promotion with Food Phytochemicals: A Strategy for Cancer Chemoprevention
• Synthesis and Phorbol Ester Binding of the Zinc-finger Like Sequences of All Protein Kinase C Isozymes
• Difference in Prognostic Factors between Stage IB and II Uterine Cervical Carcinoma Patients Treated with Radical Hysterectomy and Postoperative Radiation Therapy
• Heterozygous Ala137Pro Mutation in Keratin 12 Gene Found in Japanese with Meesmann's Corneal Dystrophy
• Selection of RNA-binding Peptides Containing an Arg-rich Motif
• Design of RNA-Binding Oligopeptides Based on Information of RNA-Binding Protein
• Apoptosis in Retinal Ganglion Cell Decrease in Human Glaucomatous Eyes
• Enhanced Expression of Foreign Gene Transferred to Mammalian Cells in vitro Using Chemically Modified Poly(L-lysine)s as Gene Carriers
• Immunohistochemical Characterization of Epithelial Cells Implanted in the Flap-Stroma Interface of the Cornea
• Inhibition by Genistein of the Lipopolysaccharide-Induced Down-Regulation of Programmed Cell Death 4 in RAW 264.7 Mouse Macrophages
• Changes in the Content and Biosynthesis of Phytoalexins in Banana Fruit
• Phenylphenalenone-type Phytoalexins from Unripe Bungulan Banana Fruit
• Possible Inhibitor of Tumor Promotion and Related Polyphenol from Lophira alata, a Medicinal Plant in Tropical West Africa(Organic Chemistry)
• Synthesis and Biological Activities of 8'-Methylene- and 8'-Methylidyneabscisic Acids
• Synthesis, Biological Activity, and Metabolism of 8', 8', 8'-Trideuteroabscisic Acid
• Intracellular Enzyme-responsive Fragmentation of Nonviral Gene Carriers Leads to Polyplex Destabilization and Enhanced Transgene Expression
• Facilitated Disassembly of Polyplexes Composed of Self-assembling Amphiphilic Polycations Enhances the Gene Transfer Efficacy
• Solid-Phase Synthesis of Amide-Linked Oligoribonucleosides and Their Properties
• Ex Vivo Transfer of Smad7 Decreases Damage to the Corneal Endothelium After Penetrating Keratoplasty
• Disodium Cromoglycate Inhibits Capsaicin-Induced Eosinophil Infiltration of Conjunctiva Independent of Mast Cells
• In Vitro Covalent Binding Proteins of Zerumbone, a Chemopreventive Food Factor
• In Vitro Covalent Binding Proteins of Zerumbone, a Chemopreventive Food Factor
• Inhibition by Genistein of the Lipopolysaccharide-Induced Down-Regulation of Programmed Cell Death 4 in RAW 264.7 Mouse Macrophages
• Chalcone Tetramers, Lophirachalcone and Alatachalcone, from Lophira alata as Possible Anti-tumor Promoters
• Synthesis and Biological Evaluation of the 12,12-Dimethyl Derivative of Aplog-1, an Anti-Proliferative Analog of Tumor-Promoting Aplysiatoxin
• Timing-controlled Decompaction of Polyplexes In Vivo Greatly Enhances Transgene Expression
• In Vitro Shoot Development of Eucalyptus citriodora on Rockwool in the Film Culture Vessel under CO_2 Enrichment
• Clinical Findings in a Choroideremia Patient Who Underwent Vitrectomy for Retinal Detachment Associated with Macular Hole
• OPA1 mutations in Japanese patients suspected to have autosomal dominant optic atrophy

もっと見る 閉じる

スポンサーリンク