In Vitro Covalent Binding Proteins of Zerumbone, a Chemopreventive Food Factor
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概要
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Zerumbone (ZER), a sesquiterpene in Zingiber zerumbet Smith, has been implicated as a promising chemopreventive agent. Here we found that ZER suppressed expression of pro-inflammatory genes (COX-2 and iNOS) and induced detoxification genes (GSTP1 and NQO1) in RAW264.7 macrophages. Using the ZER-bound Sepharose gel, it appeared ZER was covalently bound to proteins, Keap1 and HuR, that play key roles in these molecular mechanisms.
- 社団法人 日本農芸化学会の論文
著者
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MURAKAMI Akira
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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IRIE KAZUHIRO
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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OHNISHI Kohta
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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