Silymarin Attenuated the Amyloid β Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer’s Disease Mouse Model

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概要

• 論文の詳細を見る

• Alzheimer’s disease (AD) is characterized by progressive cognitive impairment and the formation of senile plaques. Silymarin, an extract of milk thistle, has long been used as a medicinal herb for liver diseases. Here we report marked suppression of amyloid β-protein (Aβ) fibril formation and neurotoxicity in PC12 cells after silymarin treatment in vitro. In vivo studies had indicated a significant reduction in brain Aβ deposition and improvement in behavioral abnormalities in amyloid precursor protein (APP) transgenic mice that had been preventively treated with a powdered diet containing 0.1% silymarin for 6 months. The silymarin-treated APP mice also showed less anxiety than the vehicle-treated APP mice. These behavioral changes were associated with a decline in Aβ oligomer production induced by silymarin intake. These results suggest that silymarin is a promising agent for the prevention of AD.

• 社団法人 日本農芸化学会の論文

著者

• Shirasawa Takuji

  Department of Aging Control, Graduate School of Medicine, Juntendo University School of Medicine

• SHIMIZU Takahiko

  Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology

• IRIE KAZUHIRO

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• MURATA Nakaba

  Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology

• MURAKAMI Kazuma

  Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology

• OZAWA Yusuke

  Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology

• KINOSHITA Noriaki

  Immuno-Biological Laboratories Co., Ltd.

• Ozawa Yusuke

  Molecular Gerontology Tokyo Metropolitan Institute Of Gerontology

• Murata Nakaba

  Molecular Gerontology Tokyo Metropolitan Institute Of Gerontology

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