Antioxidant, EUK-8, Prevents Murine Dilated Cardiomyopathy
スポンサーリンク
概要
- 論文の詳細を見る
Background: Mice lacking manganese-superoxide dismutase (Mn-SOD) activity exhibit the typical pathology of dilated cardiomyopathy (DCM). In the present study, presymptomatic and symptomatic mutant mice were treated with the SOD/catalase mimetic, EUK-8. Methods and Results: Presymptomatic heart/muscle-specific Mn-SOD-deficient mice (H/M-Sod2-/-) were treated with EUK-8 (30 mg · kg-1 · day-1) for 4 weeks, and then cardiac function and the reactive oxygen species (ROS) production in their heart mitochondria were assessed. EUK-8 treatment suppressed the progression of cardiac dysfunction and diminished ROS production and oxidative damage. Furthermore, EUK-8 treatment effectively reversed the cardiac dilatation and dysfunction observed in symptomatic H/M-Sod2-/- mice. Interestingly, EUK-8 treatment repaired a molecular defect in connexin43. Conclusions: EUK-8 treatment can prevent and cure murine DCM, so SOD/catalase mimetic treatment is proposed as a potential therapy for DCM.
- 2009-10-20
著者
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Hiraumi Yoshimi
Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine
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ADACHI Souichi
Department of Pediatrics, Kyoto University Graduate School of Medicine
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Fujita Toshiro
Department Of Nephrology And Endocrinology Faculty Of Medicine University Of Tokyo
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Ando Katsuyuki
東京都老人総合研究所 老人バイオマーカー研究
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Ando Katsuyuki
Department Of Nephrology And Endocrinology Faculty Of Medicine University Of Tokyo
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Ando Katsuyuki
Fourth Department Of Internal Medicine School Of Medicine University Of Tokyo
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Ando Katsuyuki
Department Of Nephrology And Endocrinology Faculty Of Medicine University Of Tokyo Hospital
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Fujita Toshiro
Department Of Nephrology And Endocrinology Faculty Of Medicine University Of Tokyo Hospital
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KAWAKAMI Satoru
Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology
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MATSUDA Akina
Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology
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SUNAGAWA Tadahiro
Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology
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NODA Yoshihiro
Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology
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KANEKO Takao
Redox Regulation, Tokyo Metropolitan Institute of Gerontology
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TAHARA Shoichi
Redox Regulation, Tokyo Metropolitan Institute of Gerontology
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MATSUI Hiromitsu
Department of Nephrology and Endocrinology, Faculty of Medicine, University of Tokyo
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MARUYAMA Naoki
Aging Regulation, Tokyo Metropolitan Institute of Gerontology
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SHIRASAWA Takuji
Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology
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SHIMIZU Takahiko
Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology
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Shimosawa Tatsuo
Molecular Gerontology Tokyo Metropolitan Institute Of Gerontology
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Hiraumi Yoshimi
Department Of Cardiovascular Medicine Kyoto Prefectural University Of Medicine
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Hiraumi Yoshimi
Department Of Pediatrics Kyoto University Hospital
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Fujita Toshiro
Department Of Cardiovascular Medicine University Of Tokyo School Of Medicine
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Fujita Toshiro
Department Of Nephrology And Endocrinology University Of Tokyo Graduate School Of Medicine
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Adachi Souichi
Department Of Pediatrics Kyoto University Hospital
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Adachi Souichi
Department Of Pediatrics Graduate School Of Medicine Kyoto University
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Shimizu Takahiko
東京都老人総合研究所 老人バイオマーカー研究
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Shimizu Takahiko
Department Of Molecular Gerontology Tokyo Metropolitan Institute Of Gerontology
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Shimizu Takahiko
Molecular Gerontology Tokyo Metropolitan Institute Of Gerontology
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Kawakami Satoru
Molecular Gerontology Tokyo Metropolitan Institute Of Gerontology
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Fujita T
Department Of Nephrology And Endocrinology University Of Tokyo Faculty Of Medicine
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Shirasawa Takuji
Research Team For Molecular Biomarkers Tokyo Metropolitan Istitute Of Gerontology
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Shirasawa Takuji
Department Of Molecular Gerontology Tokyo Metropolitan Institute Of Gerontology
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Shirasawa Takuji
Molecular Gerontology Tokyo Metropolitan Institute Of Gerontology
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Kaneko Takao
Redox Regulation Tokyo Metropolitan Institute Of Gerontology
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Matsuda Akina
Molecular Gerontology Tokyo Metropolitan Institute Of Gerontology
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Tahara Shoichi
Redox Regulation Tokyo Metropolitan Institute Of Gerontology
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Tahara Shoichi
Redox Regulation Research Group Tokyo Metropolitan Institute Of Gerontology
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Noda Yoshihiro
Molecular Gerontology Tokyo Metropolitan Institute Of Gerontology
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Sunagawa Tadahiro
Molecular Gerontology Tokyo Metropolitan Institute Of Gerontology
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Matsui Hiromitsu
Department Of Nephrology And Endocrinology Faculty Of Medicine University Of Tokyo
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Kaneko Takao
Redox Regulation Research Group Tokyo Metropolitan Institute Of Gerontology
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Ando Katsuyuki
Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Funatsu Takashi
Lab. Of Bioanalytical Chemistry Graduate School Of Pharmaceutical Sciences The Univ. Of Tokyo Tokyo
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Funatsu Takashi
Laboratory Of Bio-analytical Chemistry Graduate School Of Pharmaceutical Sciences The University Of
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Matsui Hiromitsu
Department Of Nephrology And Endocrinology University Of Tokyo Graduate School Of Medicine
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Maruyama Naoki
Aging Regulation Tokyo Metropolitan Institute Of Gerontology
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Fujita Toshiro
Department Of Nephrology And Endocrinology Graduate School Of Medicine The University Of Tokyo
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Shimosawa Tatsuo
Faculty Of Medicine The University Of Tokyo
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Funatsu Takashi
Laboratory Of Bio-analytical Chemistry Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Fujita Toshiro
Laboratory Of Bio-analytical Chemistry Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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ADACHI Souichi
Department of Human Health Sciences, Graduate School of Medicine, Kyoto University
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