THE EFFECT OF SODIUM AND POTASSIUM LOADING ON URINARY KALLIKREIN-LIKE ACTIVITY IN YOUNG PATIENTS WITH BORDERLINE HYPERTENSION
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概要
- 論文の詳細を見る
We studied the effects of a potassium supplement on urinary kallikrein excretion in a setting of high sodium intake after sodium deprivation with diuretics in young patients with borderline hypertension. Eleven patients, who took the potassium supplementation during the high sodium diet period, showed lower increments in mean blood pressure with salt loading than 12 patients without the potassium supplementation. In the non-potassium-supplemented patients, urinary kallikrein was increased significantly when plasma renin activity (PRA), plasma aldosterone concentration (PAC), and urinary aldosterone were increased during the diuretic treatment. It was decreased significantly when the other hormones were decreased during the sodium load. During the high sodium diet period, PRA, PAC and urinary aldosterone were greater in the potassium-supplemented patients than in the non-potassium-supplemented ones, but urinary kallikrein excretion was not higher when potassium was supplemented. Thus, the present results did not support the theory that the kallikrein-kinin system may be involved in the natriuretic and antihypertensive effects of potassium. In addition, these finding suggest that some kallikrein-modulating factor(s) may counteract the increased urinary kallikrein excretion with the augumented renin-angiotensin-aldosterone system during salt loading with potassium supplementation.
- 社団法人日本循環器学会の論文
- 1985-11-20
著者
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Fujita Toshiro
東京都老人総合研究所 老人バイオマーカー研究
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Fujita Toshiro
Department Of Nephrology And Endocrinology Faculty Of Medicine University Of Tokyo
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Fujita Toshiro
Fourth Department Of Internal Medicine School Of Medicine University Of Tokyo
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Ando Katsuyuki
東京都老人総合研究所 老人バイオマーカー研究
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Ando Katsuyuki
Fourth Department Of Internal Medicine School Of Medicine University Of Tokyo
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ITO Yasushi
Department of Neurosurgery, Brain Research Institute, Niigata University
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Ando Katsuyuki
Department Of Nephrology And Endocrinology Faculty Of Medicine University Of Tokyo Hospital
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Fujita Toshiro
Department Of Nephrology And Endocrinology Faculty Of Medicine University Of Tokyo Hospital
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Ando K
Fourth Department Of Internal Medicine University Of Tokyo School Of Medicine
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NODA Hiroshi
Department of Legal Medicine, Kinki University School of Medicine
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Fujita Toshiro
Department Of Cardiovascular Medicine University Of Tokyo School Of Medicine
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Noda H
Fourth Department Of Internal Medicine University Of Tokyo School Of Medicine
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Ito Yasushi
Fourth Department Of Internal Medicine University Of Tokyo School Of Medicine
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Ito Yasushi
Department Of Neurosurgery Brain Research Institute University Of Niigata
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Noda Hiroshi
Department Of Animal Health Faculty Of Veterinary Medicine Rakuno Gakuen University
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Ando Katsuyuki
Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Ito Yasushi
Department Of Biological Diversity Faculty Of Agriculture Gifu University
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Ito Yasushi
Department Of Biofunctional Molecules Gifu Pharmaceutical University
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ITO Yasushi
Department of Applied Chemisty, Faculty of Technology, Tokyo University of Agriculture and Technology
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