HYPOTENSIVE ACTION OF TAURINE IN DOCA-SALT RATS : Involvement of Sympathoadrenal Inhibition and Endogenous Opiate
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概要
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We studied the roles of the sympathoadrenal system and endogenous opiate in the antihypertensive effects of supplementation of dietary taurine, a sulfur amino acid. in deoxycorticosterone acetate (DOCA)-salt rats. Supplementation of 1% taurine in drinking water for 2 weeks was found to prevent the increase in systolic blood pressure of DOCA-salt rats (116±2 vs 138±mmHg, p<0.01). but failed to effect the systolic blood pressure of vehicle-treated control rats (115±2 vs 112±3mmHg). taurine supplementation restored to normal in-creased plasma norepinephrine (326±32 vs 531±67pg/ml, p<0.01) and epinephrine (204±19 vs 304±43pg/ml. p<0.05) concentrations in DOCA-salt rats, but had no effect on norepinephrine (346±23 vs 338±33pg/ml) or epinephrine (198±17 vs 224±26pg/ml) concentrations in control rats. Accordingly, the increased epinephrine content in the adrenals of DOCA-salt rats was normalized with the supplementation of taurine, associated with a markedly in-creased adrenal taurine content. In conscious rats, moreover, intraperitoneal injection of naloxone (2mg/kg). a specific opiate antagonist, increased systolic blood pressure only in taurine-supplemented DOCA-salt rats. Evidence presented suggests. therefore, that both the suppression of the increased sympathoadrenal activity and the activation of endogenous opiate might contribute to the antihypertensive effect of taurine in DOCA-salt rats.
- 社団法人日本循環器学会の論文
- 1991-05-20
著者
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Fujita Toshiro
Fourth Department Of Internal Medicine School Of Medicine University Of Tokyo
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Fujita Toshiro
Department Of Nephrology And Endocrinology Faculty Of Medicine University Of Tokyo Hospital
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SATO YUJI
Fourth Department of Internal Medicine, School of Medicine University of Tokyo
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OGATA ETSURO
Fourth Department of Internal Medicine, School of Medicine University of Tokyo
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Sato Y
Fourth Department Of Internal Medicine School Of Medicine University Of Tokyo
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Sato Yuji
Fourth Department Of Internal Medicine School Of Medicine University Of Tokyo
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Sato Y
Department Of Nursing School Of Health And Social Services Saitama Prefectural University
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Ogata Etsuro
Fourth Department Of Internal Medicine University Of Tokyo School Of Medicine
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Ogawa Etsuro
Fourth Department Of Internal Medicine. University Of Tokyo School Of Medicine And Department Of Int
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Ogata Etsuro
Fourth Department Of Internal Medicine School Of Medicine University Of Tokyo
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Sato Yuji
Department Of Nursing School Of Health And Social Services Saitama Prefectural University
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