Metabolism of Cardiac Structural Proteins in Normal and Hypertrophied Rabbit Heart
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概要
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In an attempt to elucidate the characteristics of the metabolic response of the hypertrophying heart, the rates of amino acid incorporation into cardiac structural proteins were studied in female rabbit hearts in vivo by use of a pulse-label isotope (3H-lysine) method. Hypertrophy of the left ventricle was produced by applying mild aortic constriction. Structural proteins were separated from the heart excised 24h after the pulse, and the rate of 3H incorporation was calculated as cpm 3H/mg lysine of the protein. In the control (without aortic constriction), left ventricular structural proteins exhibited the following relative incorporation rate (the rate in actin being taken as 1.0): native tropomyosin, 2.79±0.38 (mean±SE, n=5); 10S-actinin and α-actinin complex, 2.52±0.29; heavy chain of myosin, 2.09±0.25; light chain of myosin, 1.82±0.28; soluble protein, 1.79±0.30; and actin, 1.0. In the rabbits with aortic stenosis the rates of amino acid incorporation showed a striking increase up to 7 days after surgery, and declined to the control level by 1 month. Among the protein fractions, native tropomyosin and the light chain of myosin showed a much higher rate of isotopic incorporation during the earlier phase of the response. These results seem to indicate the presence of a unique pattern of metabolic response in cardiac muscle confronted with a workload.
- International Heart Journal刊行会の論文
著者
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OGATA ETSURO
Fourth Department of Internal Medicine, School of Medicine University of Tokyo
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Ebisawa Ken
4th. Dept. Of Intern. Med. Faculty Of Med. Tokyo Univ
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Ito Yoshio
Fourth Depart. Intern. Med., Facul. Med., University of Tokyo
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EBISAWA Ken
Fourth Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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KIRA Yuji
Fourth Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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KOIZUMI Tadahiro
Fourth Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Ogata Etsuro
Fourth Department Of Internal Medicine School Of Medicine University Of Tokyo
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Ito Yoshio
Fourth Depart. Intern. Med. Facul. Med. University Of Tokyo
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OGATA Etsuro
Fourth Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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