Some Observations on Serum Concentrations of Digitoxin and Digoxin
スポンサーリンク
概要
- 論文の詳細を見る
Serum concentrations of digitoxin and digoxin were measured in 145 cases with various heart diseases receiving maintenance doses of digitalis.Digitalis toxicity was seen in only 2 cases (1.4%)Day-to-day variation of serum concentration while taking the same daily dose was small in digitoxin therapy (13.8%), but a considerable variation was seen in digoxin therapy (24.4%)Serum concentrations of both digitoxin and digoxin were measured in the patients receiving digitoxin, and there was a positive correlation between the two (r=0.66, p<0.001). This fact suggested that the effect of digitoxin was the sum of the effects of digitoxin and its metabolite, digoxin. In the patients taking digoxin, digitoxin was not detected in the serumSerum digitoxin level had a significantly positive correlation to serum albumin level, presumably because digitoxin was retained in serum in the bound form to albumin. Minimal effective level, 10ng/ml, was however obtained with higher daily dose of digitoxin in patients with lower serum albumin
- International Heart Journal刊行会の論文
著者
-
SADA Toshikatsu
Fourth Department of Internal Medicine, Faculty of Medicine, The University of Tokyo
-
Takeuchi Masaya
The Fourth Department Of Internal Medicine Faculty Of Medicine The University Of Tokyo And Showa Hos
-
Takeuchi Masaya
Dept. Of Intern. Med. Tokyo Univ. Branch Hosp.
-
Ito Yoshio
Fourth Depart. Intern. Med. Facul. Med. University Of Tokyo
-
TAKAHASHI Masana
Fourth Department of Internal Medicine, Faculty of Medicine, University of Tokyo
-
TANEICHI Yoshihiro
Fourth Department of Internal Medicine, Faculty of Medicine, University of Tokyo
-
OKABE Fujiko
Fourth Department of Internal Medicine, Faculty of Medicine, University of Tokyo
-
MORISHIMA Akira
The Cardiology Division, Nakano National Chest Hospital
-
Takeuchi Masaya
Dept. Of Intern. Med. Univ. Of Tokyo
関連論文
- R WAVE CHANGES IN PATIENTS WITH MYOCARDIAL INFARCTION DURING TREADMILL STRESS TESTING
- Exercise Capacity of the Patients with Myocardial Infarction : Cardiac Rehabilitation
- THE CHANGES OF HEMOGLOBIN-OXYGEN AFFINITY DURING SHORT-TERM EXERCISE : Exercise Test : 46th Annual Scientific Meeting, Japanese Circulation Society
- THE R WAVE CHANGE DURING TREADMILL EXERCISE TEST IN MYOCARDIAL INFARCTION : Exercise Test : 46th Annual Scientific Meeting, Japanese Circulation Society
- ROLE OF HEMOGLOBIN-OXYGEN AFFINITY DURING THE EXPERIMENTAL ACUTE MYOCARDIAL INFARCTION : Ischemic heart disease : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- THE REHABILITATION OF MYOCARDIAL INFARCTION: STUDY ON THE LONG TERM CARDIAC AND PHYSICAL ACTIVITY : Ischemic Heart Disease : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- STUDY ON EXERCISE INDUCED R WAVE CHANGES IN MYOCARDIAL INFARCTION : Electrocardiography・Vectircarduigraphy I : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- EXERCISED VECTORCARDIOGRAM-CHANGES OF VECTORCARDIOGRAPHIC LOOPS : The Fifth Conference on Vectorcardiography
- CLINICAL STUDY ON T WAVE OF RIGHT VANTRICULAR OVERLOADING : Electrocardiography : IInd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- POLARCARDIOGRAPHIC DIAGNOSIS OF MYOCARDINAL INFARCTION : GROBAL PLOTTING OF HEART VECTOR : THE IV CONFERENCE ON VECTORCARDIOGRAPHY
- The Relationship between Spatial Valocity and Magnitude Electrocardiograms
- 21)EXERTIONAL CHANGES OF THE CORRELATION CURVE BETWEEN SPATIAL VELOCITY AND SPATIAL MAGNITUDE ELECTROCARDIOGRAM : THE II CONFERENCE ON VECTORCARDIOGRAPHY
- EXERCISE VECTORCARDIOGRAM : WITH SPECIAL REFERENCE TO THE CORRELATION CURVE OF SPATIAL VELOCITY AND SPATIAL MAGNITUDE ELECTROCARDIOGRAM : IVth Auditorium
- EXERCISED VECTORCARDIOGRAM STUDIES OF HIGH-GAINED ATTIAL WAVES USING THE DIRECT-WRITING VCG : Ist Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- POLARCARIOGRAPHIC RESPONSES TO TWO STEP TEST IN NORMAL, ISCHEMIC HEART DISEASE AND HYPERTENSION
- 66. Clinical Observation of Angina Pectoris, Special Reference to Angina at Rest
- 125) The Evaluation of Electrocardiographic Changes in the Patients with Coronary Heart Disease
- Myocardial Free Fatty Acid (FFA) Metabolism in Several Heart Diseases
- Studies on Acute Cardiac Death of Unknown Etiology. (1)
- In-hospital Rehabilitation at the Recovery Phase after Acute Myocardial Infarction : Cardiac Rehabilitation
- Right Coronary Artery to Left Ventricle Fistula : The Sixth Case in the Literature and Discussion
- The Relationship between Spatial Velocity and Magnitude Electrocardiograms
- Metabolism of Cardiac Structural Proteins in Normal and Hypertrophied Rabbit Heart
- Application of Medical Engineering for Exercise Tests and Management on Ischemic Heart Disease : Check-Alarm-Training System
- Some Observations on Serum Concentrations of Digitoxin and Digoxin
- Effects of Coronary Vasodilators on the Coronary Circulation in the Sclerotic Heart Disease
- Myocardial Metabolism of Individual Free Fatty Acids (FFA) in Valvular Disease as Compared with Coronary Sclerosis
- Angina Pectoris Induced by Intravenous Administration of 50% Glucose
- Primary Thrombocythemia and Myocardial Infarction in a 26-Year-Old Woman with Normal Coronary Arteriogram
- Risk factors for the complication of cerebral infarction in Japanese patients with acute myocardial infarction.
- Mechanisms for improvement of cardiac performance by nifedipine in an acute mitral regurgitation in dogs.
- Ambulatory electrocardiograms obtained by holter monitoring system in patients with permanent demand pacemakers.