Phasic plasma atrial natriuretic polypeptide changes in DOCA-salt hypertensive rats.
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概要
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We determined plasma and cardiac immunoreactive atrial natriuretic polypeptide (ir-ANP) levels in rats treated with deoxycorticosterone acetate (DOCA) and sodium chloride for 1, 7, and 28 days. Systolic blood pressure of DOCA-salt rats began to increase from the 7th day and reached 191±7mmHg at the 28th day. One day after treatment with DOCA-salt, plasma levels of ir-ANP were increased compared to that of control rats. This was accompanied by decreased cardiac ir-ANP content. However, at the 7th day of DOCA-salt treatment, both plasma and cardiac ir-ANP levels of DOCA-salt rats were not different from those of control animals. At the 28th day, DOCA-salt rats had high plasma irANP levels and no significantly different cardiac ir-ANP content compared to the controls. These data suggest that there are time-related changes in plasma ANP concentration during the development of DOCA-salt hypertension and higher plasma ANP levels might not necessarily be associated with a decreased cardiac ANP content.
- International Heart Journal刊行会の論文
著者
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Fujita Toshiro
Fourth Department Of Internal Medicine School Of Medicine University Of Tokyo
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Ando Katsuyuki
Fourth Department Of Internal Medicine School Of Medicine University Of Tokyo
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Ito Yasushi
Fourth Department Of Internal Medicine University Of Tokyo School Of Medicine
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Sato Yuji
Fourth Department Of Internal Medicine School Of Medicine University Of Tokyo
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Ogata Etsuro
Fourth Department Of Internal Medicine School Of Medicine University Of Tokyo
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ANDO Katsuyuki
Fourth Department of Internal Medicine, School of Medicine, University of Tokyo
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FUJITA Toshiro
Fourth Department of Internal Medicine, School of Medicine, University of Tokyo
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