Evidence for Increased Sympatho-adrenomedullary Activity in Young Subjects with Borderline Hypertension : THE 17th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
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概要
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Three different studies were performed to estimate the sympatho-adrenomedullary activity in young subjects with borderline hypertension (BHT, n = 40), compared with age-matched normotensive subjects (NT, n = 24). In the first study, 23 BHT and 9 NT were subjected to isometric stress by maintaining handgrip at the 30% level of maximal voluntary contraction for 3 min. The response of plasma total catecholamines at the second and third min during the isometric exercise were greater in BHT than in NT (98.9 ± 24.3 vs. 18.0 ± 30.7 and 93.0 ± 12.6 vs. 47.1 ± 15.4 pg/ml, respectively, p<0.05). In the second study, the effects of intravenous glucagon injection (1 USP unit) were studied in 12 BHT and 9 NT. The increments of plasm epinephrine (E) at 2 and 3 min after injection were significantly greater in BHT than those in NT: 44.1 ± 12.3 vs. 5.1 ± 4.4 pg/ml, and 68.9 ± 13.2 vs. 32.1 ± 8.9 pg/ml, respectively, p<0.05. In the last study, the pressor effects of intravenous norepinephrine (NE) infusion (100 and 200 ng/kg/min for 15 min) were examined in 17 BHT and 15 NT under three different sodium balances: regular customary diet, treatment with diuretics and high-sodium diet. Treatment with diuretics decreased and high-sodium diet increased the pressor response to NE in both groups, but there were no significant differences in NE reactivity between 2 groups throughout the study. The increments in mean blood pressure after NE infusion (200 ng/kg/min) on the three experimental periods correlated significantly with their preinfusion plasma NE concentrations in both BHT and NT: r = -0.58 (p<0.01) and r = -0.54 (p<0.01), respectively. Neither the slopes of these regression lines nor their intercepts differed between the 2 groups. Thus, BHT had augmented responses of plasma catecholamine to both isometric exercise and glucagon stimulation without vascular hyperreactivity to NE. Evidence presented suggests that the responses of both sympathetic nervous system and adrenal medulla to stress are increased in BHT.
- 社団法人日本循環器学会の論文
- 1988-11-20
著者
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Fujita Toshiro
東京都老人総合研究所 老人バイオマーカー研究
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Fujita Toshiro
Department Of Nephrology And Endocrinology Faculty Of Medicine University Of Tokyo
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Fujita Toshiro
Fourth Department Of Internal Medicine School Of Medicine University Of Tokyo
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Ando Katsuyuki
東京都老人総合研究所 老人バイオマーカー研究
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Ando Katsuyuki
Fourth Department Of Internal Medicine School Of Medicine University Of Tokyo
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ITO Yasushi
Department of Neurosurgery, Brain Research Institute, Niigata University
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Ando Katsuyuki
Department Of Nephrology And Endocrinology Faculty Of Medicine University Of Tokyo Hospital
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Fujita Toshiro
Department Of Nephrology And Endocrinology Faculty Of Medicine University Of Tokyo Hospital
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Ando K
Fourth Department Of Internal Medicine University Of Tokyo School Of Medicine
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NODA Hiroshi
Department of Legal Medicine, Kinki University School of Medicine
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Fujita Toshiro
Department Of Cardiovascular Medicine University Of Tokyo School Of Medicine
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Noda H
Fourth Department Of Internal Medicine University Of Tokyo School Of Medicine
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Ito Yasushi
Fourth Department Of Internal Medicine University Of Tokyo School Of Medicine
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Ito Yasushi
Department Of Neurosurgery Brain Research Institute University Of Niigata
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Noda Hiroshi
Department Of Animal Health Faculty Of Veterinary Medicine Rakuno Gakuen University
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Ando Katsuyuki
Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Ito Yasushi
Department Of Biological Diversity Faculty Of Agriculture Gifu University
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Ito Yasushi
Department Of Biofunctional Molecules Gifu Pharmaceutical University
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ITO Yasushi
Department of Applied Chemisty, Faculty of Technology, Tokyo University of Agriculture and Technology
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