Hemodynamic Changes Associated with Long-term Antihypertensive Therapy with New Calcium Antagonist
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概要
- 論文の詳細を見る
To evaluate the therapeutic efficacy of a new calcium antagonist, nicardipine in hypertension, the cardiovascular effects of chronic therapy were determined by echocardiography in 10 patients with uncomplicated mild to moderate hypertension. Significant declines were recorded in mean blood pressure (average; 11.7±0.8%) and total peripheral resistance (22.0±2.0%), accompanied by an increase in cardiac index (13.6±2.2%). In spite of the considerable degree of blood pressure reduction, heart rate and body weight were unchanged. The magnitude of the decline in total peripheral resistance was directly correlated to both the decrease in mean blood pressure (r=0.701, p<0.02) and the increase in cardiac index (r=-0.953, p<0.01). These findings suggest that the hypotensive effect of this new calcium antagonist is due to peripheral vasodilation, and it appears to represent an effective adjunct for the treatment of mild to moderate hypertension.
- International Heart Journal刊行会の論文
著者
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Fujita Toshiro
Department Of Nephrology And Endocrinology Faculty Of Medicine University Of Tokyo
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NODA Hiroshi
Department of Legal Medicine, Kinki University School of Medicine
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Fujita Toshiro
Department Of Cardiovascular Medicine University Of Tokyo School Of Medicine
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Noda Hiroshi
Department Of Animal Health Faculty Of Veterinary Medicine Rakuno Gakuen University
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FUJITA TOSHIRO
Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
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Noda Hiroshi
Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
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