Measurement of Catechol-O-methyltransferase Activity in the Brain of Dahl Salt-Sensitive Rats(Analytical Biochemistry)
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概要
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Metabolism by catechol-O-methyltransferase (COMT) is one of the inactivation pathways of catecholamines (CAs), which are important hormones in regulating blood pressure both in central and in peripheral sympathetic nerve endings. We have reported the rapid determination method of COMT activity using high-performance liquid chromatography (HPLC)-fluorescence detection. In the present study, we applied the method to brain tissues, cerebral cortex, cerebellum, hypophysis and hypothalamus. COMT activities were assessed by measuring normetanephrine with the use of norepinephrine as an endogenous substrate. We examined the COMT activities in the brains of Dahl salt-sensitive (DS) rats given normal-salt or high-salt diet for 13 weeks, and found that membrane-bound COMT activities in the cerebral cortex were significantly reduced in high-salt loaded DS rats compared with normal-salt loaded DS rats.
- 社団法人日本薬学会の論文
- 2007-11-01
著者
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Fujita Toshiro
Department Of Nephrology And Endocrinology Faculty Of Medicine University Of Tokyo
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Fujita Toshiro
Department Of Nephrology And Endocrinology Faculty Of Medicine University Of Tokyo Hospital
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Shimosawa Tatsuo
Molecular Gerontology Tokyo Metropolitan Institute Of Gerontology
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Tsunoda Makoto
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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Funatsu Takashi
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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Fujita Toshiro
Department Of Nephrology And Endocrinology University Of Tokyo Graduate School Of Medicine
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Funatsu Takashi
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Tsunoda Makoto
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Tsunoda Makoto
Laboratory Of Bio-analytical Chemistry Graduate School Of Pharmaceutical Sciences The University Of
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HIRANO Yoko
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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SHIMOSAWA Tatsuo
Faculty of Medicine, The University of Tokyo
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FUJITA Toshiro
Faculty of Medicine, The University of Tokyo
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Shimizu Takahiko
東京都老人総合研究所 老人バイオマーカー研究
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Fujita T
Department Of Nephrology And Endocrinology University Of Tokyo Faculty Of Medicine
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Shirasawa Takuji
Research Team For Molecular Biomarkers Tokyo Metropolitan Istitute Of Gerontology
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Shirasawa Takuji
Department Of Molecular Gerontology Tokyo Metropolitan Institute Of Gerontology
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Hirano Yoko
Laboratory Of Bio-analytical Chemistry Graduate School Of Pharmaceutical Sciences The University Of
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Funatsu Takashi
Lab. Of Bioanalytical Chemistry Graduate School Of Pharmaceutical Sciences The Univ. Of Tokyo Tokyo
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Funatsu Takashi
Laboratory Of Bio-analytical Chemistry Graduate School Of Pharmaceutical Sciences The University Of
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Fujita Toshiro
Department Of Nephrology And Endocrinology Graduate School Of Medicine The University Of Tokyo
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Shimosawa Tatsuo
Faculty Of Medicine The University Of Tokyo
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Funatsu Takashi
Laboratory Of Bio-analytical Chemistry Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Fujita Toshiro
Laboratory Of Bio-analytical Chemistry Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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