Significant Role of α_2-Adrenoceptors in Coronary Artery Spasm : SYMPOSIUM ON PATHOGENESIS OF CORONARY ARTERY SPASM

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概要

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• Ergnovine, methoxamine and clonidine were administered intravenously in order to clarify the mechanism of coronary artery spasm in canine experiments. After these administrations, 27.5% of the dogs treated with ergonovine, 59.5% of the dogs treated with methoxamine and 72.7% of the dogs treated with clonidine showed ST segment elevation. The combined application of propranolol with ergonovine or methoxamine could more easily induce ST segment elevation than a single application of ergonovine or methoxamine. Most cases of elevated ST segment returned to the normal after the administration of nitroglycerin and phentolamine. Yohimbine was completely effective for the restoration of normal ST segment. Plasma norepinephrine decreased to 20±8.0% of the control when ST segment elevation was induced. This is a significantly greater decrease than that seen without ST segment elevation (p<0.001). Concomitant with the restoration of normal ST segment, plasma norepinephrine increased after the administration of yohimbine. Methoxamine and clonidine increased (p<0.01) and yohimbine decreased (p<0.01) and yohimbine decreased (p<0.01) coronary vascular resistance. Coronary spasm was visualized on coronary arteriogram after the application of clonidine; also coronary vascodilation was visualized after the administration of yohimbine. These results confirm the hypothesis that coronary artery spasm is mediated by pre- and postsynapic _2-adrenoceptors.

• 社団法人日本循環器学会の論文
• 1985-01-20

著者

• Sugishita Yasuro

  Department or Internal Medicine, University of Tsukuba

• Ito Iwao

  Department of Internal Medicine University of Tsukuba

• Ohtsuka Sadanori

  Department of Internal Medicine, Institute of Clinical Medicien, University of Taukuba

• NODA Hiroshi

  Department of Legal Medicine, Kinki University School of Medicine

• Ohtsuka Sadanori

  Department Of Internal Medicine Institute Of Clinical Medicien University Of Taukuba

• Kakihana Masaaki

  Department of Medicine, Institute of Clinical Medicine, University of Tsukuba

• Kakihana Masaaki

  Ibaraki Prefectural University of Health Sciences, Ami

• Ohtsuka Sadanori

  Cardiovascular Medicine Institute Of Clinical Medicine Graduate School Of Comprehensive Human Scienc

• Ohtsuka Sadanori

  Departments Of Cardiology Institute Of Clinical Medicine University Of Tsukuba

• Sugishita Yasuro

  Departments Of Cardiology Institute Of Clinical Medicine University Of Tsukuba

• Kakihana Masaaki

  Ibaraki Prefectural University Of Health Sciences

• Kakihana Masaaki

  Department Of Cardiology Tsukuba Memorial Hospital

• Ito Iwao

  The Second Department Of Internal Medicine University Of Tokyo.

• Noda Hiroshi

  Department Of Animal Health Faculty Of Veterinary Medicine Rakuno Gakuen University

• Ito Iwao

  Department Of Internal Medicine Institute Of Clinical Medicine Institute Of Basic Medicine Tsukuba U

• Ohtsuka Sadanori

  Department Of Internal Medicine The University Of Tsukuba

• Kazama Masahiro

  Institute Of Clinical Medicine University Of Tsukuba

• Sugishita Yasuro

  Department Of Intensive Care Anesthesiology Surgery And Internal Medicine Univ.of Tsukuba

• Ohtsuka Sadanori

  Department Of Cardiology University Of Tsukuba Graduate School Of Comprehensive Human Sciences

• Kakihana Masaaki

  Department Of Medicine Institute Of Clinical Medicine University Of Tsukuba

• Noda Hiroshi

  Department Of Medicine Institute Of Clinical Medicine The University Of Tukuba

• Kakihana Masaaki

  2nd Dept. Of Internal Medicine Fac. Of Medicine Univ. Of Tokyo.

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