Synthesis and properties of cationic polynucleotide analog binding RNase A.
スポンサーリンク
概要
- 論文の詳細を見る
A new type of cationic polynucleotide analog binding RNase A and its related compounds were synthesized from an insoluble cross-linked poly(4-vinylpyridine). The cross-linked poly(4-vinylpyridine) was converted into an aldehyde derivative by the reaction with cyanogen bromide. The aldehyde derivative was used for the binding of RNase A and 9-(2-aminoethyl)adenine through their amino groups. The cationic adenine polynuleotide analog binding RNase A favorably interacted with nucleotides containing uracil base through the base-specific interactions. This analog showed the considerable selectivity in the hydrolysis of uridine polynucleotide owing to the template effect.
- 公益社団法人 日本化学会の論文
著者
-
Murakami Akira
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
-
Shimidzu Takeo
Division Of Molecular Engineering Graduate School Of Engineering Kyoto University
-
Murakami Akira
Division of Molecular Engineering, Kyoto University
-
Yamana Kazushige
Division of Molecular Engineering, Kyoto University
関連論文
- Lack of Enhancing Effect of Lauric Acid on the Development of Aberrant Crypt Foci in Male ICR Mice Treated with Azoxymethane and Dextran Sodium Sulfate
- Combinatorial Effects of Nonsteroidal Anti-inflammatory Drugs and Food Constituents on Production of Prostaglandin E_2 and Tumor Necrosis Factor-α in RAW264.7 Murine Macrophages(Food & Nutrition Science)
- Suppressive Effects of Natural and Synthetic Agents on Dextran Sulfate Sodium-induced Interleukin-1β Release from Murine Peritoneal Macrophages
- Ursolic Acid Enhances Cyclooxygenases and Tumor Necrosis Factor-α Expression in Mouse Skin
- Suppressive Effects of Selected Antioxidants on the Activated Leukocytes-induced Mutagenesis in the Co-culture Assay Systems
- Auraptene Decreases the Activity of Matrix Metalloproteinases in Dextran Sulfate Sodium-Induced Ulcerative Colitis in ICR Mice
- Nobiletin, a Citrus Flavonoid, Down-Regulates Matrix Metalloproteinase-7 (matrilysin) Expression in HT-29 Human Colorectal Cancer Cells
- Photochemical Polymerization of Dithienothiophenes
- Photochemical Polymerization of Oligothiophenes
- Synthesis of Poly(isothianaphthene) by Photopolymerization of 1,3-Dihydroisothianaphthene
- In Vitro Covalent Binding Proteins of Zerumbone, a Chemopreventive Food Factor
- Inhibition by Genistein of the Lipopolysaccharide-Induced Down-Regulation of Programmed Cell Death 4 in RAW 264.7 Mouse Macrophages
- Synthesis and Photochemical Properties of the Orthogonal Porphyrin Triad Composed of Free-Base and Phosphorus(V) Porphyrins
- Preparation of Polyviologen-modified TiO_2 by Photocatalytic Polymerization of Bis(4-cyano-1-pyridinio )- P-xylene Dibromide
- Synthesis and Biological Evaluation of the 12,12-Dimethyl Derivative of Aplog-1, an Anti-Proliferative Analog of Tumor-Promoting Aplysiatoxin
- Suppression of CD74 Expression and Helicobacter pylori Adhesion by Auraptene Targeting Serum Starvation-Activated ERK1/2 in NCI-N87 Gastric Carcinoma Cells
- Zerumbone Suppresses Phorbol Ester-Induced Expression of Multiple Scavenger Receptor Genes in THP-1 Human Monocytic Cells
- Modifying Effects of Dietary Factors on (-)-Epigallocatechin-3-gallate-induced Pro-matrix Metalloproteinase-7 Production in HT-29 Human Colorectal Cancer Cells
- Synthesis and Biological Evaluation of the 12,12-Dimethyl Derivative of Aplog-1, an Anti-Proliferative Analog of Tumor-Promoting Aplysiatoxin
- 1,2-Di-O-α-linolenoyl-3-O-β-galactosyl-sn-glycerol as a Superoxide Generation Inhibitor from Perilla frutescens var. crispa
- Low and Medium but Not High Doses of Green Tea Polyphenols Ameliorated Dextran Sodium Sulfate-Induced Hepatotoxicity and Nephrotoxicity
- Synthesis of bis(deoxyribonucleoside) phosphoromorpholidate derivatives for oligodeoxyribonucleotide preparation by use of a selective phosphitylating reagent.
- Effective doping of polymer anion during chemical polymerization of pyrrole using Fe(OH)3 oxidant.
- Syntheses and properties of oligothymidylate analogs containing stereoregulated phosphoromorpholidate and phosphodiester linkages in an alternating manner.
- Synthesis and properties of cationic polynucleotide analog binding RNase A.