1,2-Di-O-α-linolenoyl-3-O-β-galactosyl-sn-glycerol as a Superoxide Generation Inhibitor from Perilla frutescens var. crispa
スポンサーリンク
概要
- 論文の詳細を見る
Using a superoxide (O2−) generation assay system with differentiated HL-60 cells, 1,2-di-O-α-linolenoyl-3-O-β-galactosyl-sn-glycerol (DLGG) was identified as an O2− generation inhibitor from Perilla frutescens var. crispa (a local variety, kida-chirimen shiso). DLGG suppressed the O2− level in a dose-dependent manner with an IC50 value of 21 μM, comparable to those of rosmarinic acid (RoA, IC50=29 μM) and caffeic acid (CA, IC50=30 μM). While RoA and CA also dose-dependently inhibited O2− generation in a xanthine-xanthine oxidase system, DLGG had no effect in the same system. Thus DLGG appeared to decrease the O2− level in the HL-60 assay system by mechanisms different from those of RoA and CA, which appeared to act as O2− scavengers.
- 社団法人 日本農芸化学会の論文
- 2011-11-23
著者
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Ohigashi Hajime
Department Of Food Science And Technology Faculty Of Agriculture Kyoto University
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Kubo Yoshito
Fukui Prefectural Food Processing Research Institute
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Murakami Akira
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Irie Kazuhiro
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Ohigashi Hajime
Div. Of Food Sci. And Biotechnology Graduate School Of Agriculture Kyoto Univ.
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Takahashi Yu
Department Of Microbiology And Molecular Pathology Faculty Of Pharmaceutical Sciences Teikyo Univers
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Kawabata Kyuichi
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Takahashi Masakazu
Department Of Food Science And Technology Faculty Of Agriculture Kyoto University
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Kawabata Kyuichi
Department Of Bioscience Faculty Of Biotechnology Fukui Prefectural University
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SUGIYAMA Yuta
Department of Bioscience, Faculty of Biotechnology, Fukui Prefectural University
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KOBAYASHI Kyoichi
Fukui Prefectural Food Processing Research Institute
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Sugiyama Yuta
Department Of Bioscience Faculty Of Biotechnology Fukui Prefectural University
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Takahashi Yu
Department Of Bioscience Faculty Of Biotechnology Fukui Prefectural University
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Takahashi Masakazu
Department Of Bioscience Faculty Of Biotechnology Fukui Prefectural University
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Ohigashi Hajime
Department Of Bioscience Faculty Of Biotechnology Fukui Prefectural University
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Murakami Akira
Department Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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