α-Smooth Muscle Actin-positive Stromal Cells Reactive to Estrogens Surround Endometrial Glands in Rats but not Mice

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概要

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• In human endometrium, α-smooth muscle actin (α-SMA)-positive stromal cells (SMA-SCs) surround endometrial glands, and the α-SMA expression is regulated by estrogen. The biological significance of these cells remains to be elucidated, and no information is available with regard to their animal counterparts. The present study, therefore, investigated SMA-SCs in the uteri of female Donryu rats and CD-1 mice. SMA-SCs with morphological similarities to those in the human were detected around the endometrial glands in normal cycling rats, but not in mice. Furthermore, the rat SMA-SCs disappeared after ovariectomy but returned with estrogen replacement in a duration-dependent manner, suggesting the regulatory role of estrogens similar to the human situation. Thus, SMA-SCs are present in rats, but not in mice, with characteristics close to their human counterparts. Their biological significance now needs to be elucidated by comparative studies.

• 日本毒性病理学会の論文
• 2005-03-30

著者

• NAKAE Dai

  Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health

• Nakae Dai

  東京都健康安全研究センター

• Nakae Dai

  Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health:toky

• Nakae Dai

  Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health

• MAEKAWA Akihiko

  Chemical Management Center, National Institute of Technology and Evaluation

• Yoshida Midori

  National Institute of Health Sciences

• UEMATSU Fumiyuki

  Department of Pathology, Sasaki Institute

• YOSHIDA Midori

  Department of Pathology, Sasaki Institute

• TAKAHASHI Masakazu

  Department of Pathology, Sasaki Institute

• Yoshida Midori

  Div. Of Pathology National Inst. Of Health Sciences

• Yoshida Midori

  Department Of Pathology Sasaki Institute

• SHIMOMOTO Takasumi

  Department of Pathology, Sasaki Institute

• KATSUDA Shin-ichi

  Department of Biological Safety Research, Tama laboratory, Japan Food Research Laboratories

• KUNIYASU Hiroki

  Department of Molecular Pathology, Nara Medical University

• MAEKAWA Akihiko

  Sasaki Institute

• Shimomoto T

  Department Of Pathology Sasaki Institute

• Maekawa A

  Chemical Management Center National Inst. Of Technol. And Evaluation

• Maekawa Akihiko

  Chemical Management Center National Institute Of Technology And Evaluation

• Kuroda Hiroyuki

  Department Of Molecular Pathology Nara Medical University

• Maekawa Akihiko

  Safety Assessment Division Chemical Management Center National Institute Of Technology And Evaluatio

• Katashima S

  Sasaki Inst. Tokyo Jpn

• Takahashi Masakazu

  Division Of Pathology National Institute Of Health Sciences

• Takahashi Masakazu

  Department Of Microbiology Niigata College Of Pharmacy

• Katsuda Shin-ichi

  Department Of Biological Safety Research Tama Laboratory Japan Food Research Laboratories

• Uematsu Fumiyuki

  Department Of Pathology Sasaki Institute Sasaki Foundation

• Kuniyasu Hiroki

  Department Of Molecular Pathology Nara Medical University

• Shimomoto Takasumi

  Department Of Pathology Sasaki Institute

• Nakae Dai

  Department Of Pathology Sasaki Institute

• Takahashi Miwa

  National Institute of Health Sciences

• Takahashi Masakazu

  Department Of Pathology Sasaki Institute Sasaki Foundation

• Takahashi Masakazu

  National Institute Of Health Sciences

• Takahashi Masakazu

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Takahashi Masakazu

  Department Of Bioscience Faculty Of Biotechnology Fukui Prefectural University

• SHIMOMOTO Takasumi

  Department of Molecular Pathology, Nara Medical University

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