SEQUENTIAL ALTERATIONS IN CLINICAL BIOCHEMICAL INDICATORS OF RENAL FUNCTION IN 5/6 NEPHRECTOMIZED RATS : BASIC STUDY FOR RENAL TOXICITY USING 5/6 NEPHRECTOMIZED RATS
スポンサーリンク
概要
- 論文の詳細を見る
It has been established that progression of renal lesions in 5/6 nephrectomized rats, in which the total right kidney was removed and two poles of the left kidney were excised surgically, and are used as an animal model of renal failure in man, can be morphologically divided into three stages. In the present study, for establishing a renal toxicity study using this animal model on the physiological side, changes of biochemical parameters were sequentially investigated in 20 male 5/6 nephrectomized Wistar rats until 26 weeks after nephrectomy. Creatinine clearance (CLcre) and water as well as electrolyte reabsorption (FR water and FR Na, K, Cl) were reduced at weeks 2-4, then increased slightly from weeks 6 to 10, and reduced again thereafter. On the countrary, urinary protein was elevated throughout the experimental period, while albumin fraction was incereased after week 2 and low-molecular tubular protein increased after week 6 by electrophoresis. Urinary LDH also demonstrated high levels throughout the observation period, but ALP only increased after week 18. The present study thus confirmed that renal functon after 5/6 nephrectomy is indeed changed in three stages with clinical biochemical parameters, especially CLcre and FR Na, K, Cl being good indicators to distinguish the three stages of glomerular and tubular dysfunction, respectively. In addition, urinary protein-fractions by electrophoresis in this animal model were examined for the first time, proving useful approach to glomerular and tubular dysfunction.
- 日本トキシコロジー学会の論文
著者
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MAEKAWA AKIHIKO
Department of Pathology, Sasaki Institute
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YOSHIDA Midori
Department of Pathology, Sasaki Institute
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Yoshida Midori
Department Of Pathology Sasaki Institute
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Yoshida M
National Agricultural Research Center For Hokkaido Region
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Yoshida M
Genomic Sciences Center Riken
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HOKAO Ryoji
Institute for Animal Reproduction
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Yoshida Midori
Dept.pathol. Sasaki Inst.
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Maekawa A
Chemical Management Center National Inst. Of Technol. And Evaluation
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Maekawa Akihiko
Department Of Pathology Nagoya City University Medical School
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BARATA Kyoko
Department of Toxicity, Imamichi Institute for Animal Reproduction
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HOKAO Ryoji
Department of Toxicity, Imamichi Institute for Animal Reproduction
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Maekawa Akihiko
Safety Assessment Division Chemical Management Center National Institute Of Technology And Evaluatio
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Matsuda Yuzuru
President Kyowa Hakko Kogyo Co. Ltd.
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Yoshida M
National Food Research Institute
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Hokao R
Inst. For Animal Reproduction
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Hokao Ryoji
Imamichi Institute For Animal Reproduction
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Barata Kyoko
Imamichi Institute For Animal Reproduction
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Yamasaki M
Biofrontier Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Yoshida M
Department Of Pathology Sasaki Institute
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BARADA Kyoko
Imamichi Institute for Animal Reproduction
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Yoshida M
Kyowa Hakko Kogyo Co. Ltd. Tokyo Jpn
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Barada Kyoko
Imamichi Inst.ani.repro.
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Barata Kyoko
Department Of Toxicity Imamichi Institute For Animal Reproduction
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Hokao Ryoji
Department Of Toxicity Imamichi Institute For Animal Reproduction
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