Isolation and Purification of HS-142-1, a Novel Nonpeptide Antagonist for the Atrial Natriuretic Peptide Receptor, from Aureobasidium sp.(Biological Chemistry)
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概要
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During the screening program for atrial natriuretic peptide (ANP) receptor ligands of microbial origin, we isolated a novel nonpeptide ANP antagonist, HS-142-1, from a culture broth of Aureobasidium pullulans var. melanigenum. Structural analysis showed that HS-142-1 was composed of 20-30 kinds of β-1,6-glucan esterified by caproyl groups; each component had an almost equal potency. HS-142-1 inhibited [^<125>I]-rANP binding to its receptor in rabbit kidney cortex membranes with an IC_<50> of 0.3μg/ml and antagonized ANP-induced cGMP production by bovine lung membranes in a dose-dependent fashion. The discovery of this nonpeptide ANP antagonist, HS-142-1, will provide a useful tool to study the physiological significance of natriuretic peptide system.
- 社団法人日本農芸化学会の論文
- 1991-12-23
著者
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Suzuki Yasuhiro
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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ANDO Katsuhiko
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Suzuki Y
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Ando K
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Yoshida M
National Agricultural Research Center For Hokkaido Region
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MATSUDA YUZURU
Tokyo Research Laboratories, kyowa Hakko Kogyo Co., Ltd
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SAITOH Yutaka
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Asano Kozo
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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KAWAMOTO Isao
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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SANO Hiroshi
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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KASE Hiroshi
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Sano Hiroshi
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.:(present Office)shimizu Research Laboratories
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MORISHITA Yoshikazu
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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TAKAHASHI Mitsuru
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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SANO Tomoyuki
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Matsuda Yuzuru
President Kyowa Hakko Kogyo Co. Ltd.
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Matsuda Yuzuru
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Saitoh Yutaka
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Ando Katsuhiko
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd
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Kawamoto Isao
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Kawamoto Isao
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Sakai Y
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Kase H
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Kase Hiroshi
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Toki S
Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe University
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Teshiba S
Kyowa Hakko Kogyo Co. Ltd. Tokyo Jpn
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Ando Katsuhiko
Department Of Medical Zoology School Of Medicine
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Takahashi Mitsuru
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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