Calmodulin Antagonistic Action of KS-504a, a Novel Metabolite of the Fungus Mollisia ventosa(Biological Chemistry)
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概要
- 論文の詳細を見る
KS-504a inhibited bovine brain calmodulin-dependent cyclic nucleotide phosphodieaterase (CaM-PDE) with an IC_<50> value of 122μM. The inhibition was reversed by a high concentration of calmodulin. Calmodulin-independent activities of the enzyme were not affected by the compound at the same concentration ranges. Ca^<2+>-dependent interaction of the compounds with calmodulin was shown using hydrophobic fluorescence probes. These data indicated that the compound exerted its effects on CaM-PDE by interacting with calmodulin. KS-504a also inhibited other calmodulin-dependent enzymes at different concentration ranges; myosin light chain kinase was inhibited at the lowest concentrations with an IC_<50> value of 6.3μM. The inhibition mechanism was competetive with respect to calmodulin and non-competetive to ATP.
- 社団法人日本農芸化学会の論文
- 1990-10-23
著者
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Nakanishi Satoshi
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Kase Hiroshi
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.:(present Office)pharmaceutical Research Labor
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Kase Hiroshi
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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KURODA Kazutoshi
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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OSAWA Keiko
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Kuroda Kazutoshi
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Osawa Keiko
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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