Isolation of Myosin Light Chain Kinase Inhibitors from Microorganisms : Dehydroaltenusin, Altenusin, Atrovenetinone, and Cyclooctasulfur

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概要

• 論文の詳細を見る

• Dehydroaltenusin, cyclooctasulfur, atrovenetinone, and altenusin were isolated from the culture broths of Penicillium verruculosum IAM-13756, Streptomyces verticillus subsp. tsukushiensis ATCC-21633, Penicillium sp. SPC-16375, and Penicillium sp. SPC-16524, respectively, as new myosin light chain kinase (MLCK) inhibitors. These compounds inhibited the calmodulin-dependent activity of MLCK with IC_<50> values of 0.69, 0.86, 3.7, and 340 μM, respectively. Among them, dehydroaltenusin was the best MLCK inhibitor in terms of potency and selectivity examined in the purified enzyme systems.

• 社団法人日本農芸化学会の論文
• 1995-07-23

著者

• Suzuki Yasuhiro

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• ANDO Katsuhiko

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• Suzuki Y

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Ando K

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Yoshida M

  National Agricultural Research Center For Hokkaido Region

• MATSUDA YUZURU

  Tokyo Research Laboratories, kyowa Hakko Kogyo Co., Ltd

• NAKANISHI SATOSHI

  Tokyo Research Laboratories, kyowa Hakko Kogyo Co., Ltd

• TOKI Shinichiro

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• SAITOH Yutaka

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• TSUKUDA Eiji

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• Toki Shinichiro

  Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.

• Asano Kozo

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Nakanishi Satoshi

  Strategic Planning Department Pharmaceuticals Company Kyowa Hakko Kogyo Co. Ltd.

• Nakanishi Satoshi

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Matsuda Yuzuru

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Saitoh Yutaka

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Ando Katsuhiko

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd

• TSUKUDA Eiji

  ULSI Research and Development Center, Mitsubishi Electric Corporation

• Sakai Y

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Tsukuda E

  Kyowa Hakko Kogyo Co. Ltd. Shizuoka Jpn

• Tsukuda Eiji

  Ulsi Research And Development Center Mitsubishi Electric Corporation

• Ando Katsuhiko

  Department Of Medical Zoology School Of Medicine

• Nakanishi S

  Strategic Planning Department Pharmaceuticals Company Kyowa Hakko Kogyo Co. Ltd.

• Kawahara Kiyotaka

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• Yoshida M

  Kyowa Hakko Kogyo Co. Ltd. Tokyo Jpn

• Kawahara Kiyotaka

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Nakanishi S

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

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