K-254-I(Genistein), a New Inhibitor of Ca^<2+> and Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase from Streptosporangium vulgare(Biological Chemistry)

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概要

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• A new calmodulin antagonist, genistein, was isolated from the culture broth of Strepto-sporangium vulgare K-354. The spectral data of K-254-I indicated that the compound was identical with genistein, 4',5,7-trihydroxyisoflavone. Genistein inhibited the Ca^<2+>/calmodulin-dependent activity of cyclic nucleotide phosphodiesterase from bovine brain (IC_<50>=20μM) without appreciably affecting its basal activity. The inhibitory activity of genistein was antagonizede by higher concentrations of calmodulin. Although phosphatidylserine did not reverse the inhibition of calmodulin, genistein inhibited the phospholipid-sensitive, Ca^<2+>-dependent protein kinase (protein kinase C) from bovine brain (IC_<50>=35.3μM). The activity of cAMP-dependent protein kinase was not affected by 700μM of genistein.

• 社団法人日本農芸化学会の論文
• 1987-11-23

著者

• ANDO Katsuhiko

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• Ando K

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• MATSUDA YUZURU

  Tokyo Research Laboratories, kyowa Hakko Kogyo Co., Ltd

• Asano Kozo

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• GOTO Joji

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• KAWAMOTO Isao

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• YASUZAWA Tohru

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• SHIRAHATA Kunikatsu

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• SANO Hiroshi

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• KASE Hiroshi

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• Sano Hiroshi

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.:(present Office)shimizu Research Laboratories

• Matsuda Yuzuru

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Ando Katsuhiko

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd

• Kawamoto Isao

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Kawamoto Isao

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Goto Joji

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Yasuzawa T

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Kase H

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Kase Hiroshi

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Ando Katsuhiko

  Department Of Medical Zoology School Of Medicine

• Shirahata Kunikatsu

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Yasuzawa Tohru

  Analytical & Pharmacokinetic Laboratories Pharmaceutical Research Institute Kyowa Hakko Hagyo Co

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