Biochemical and Pharmacological Properties of 5-Lipoxygenase Inhibitor KF8940(Biological Chemistry)
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概要
- 論文の詳細を見る
2-n-Heptyl-4-hydroxyquinoline-N-oxide (KF8940), isolated from Pseudomonas methanica, was a potent and selective inhibitor of the arachidonate 5-lipoxygenase of rat basophilic leukemia (RBL-1) cells. Kinetic analysis indicated that the inhibitory mode was non competitive. The Ki value was 3.5×10^<-7> M. KF8940 also inhibited 12-lipoxygenase of bovine platelets in a non-competitive manner, but with a Ki value of 7×10^<-5> M. Ionophore A23187-stimulated SRS generation from rat peritoneal cells and antigen-stimulated SRS-A generation from sensitized rat lung were significantly inhibited by KF8940. KF8940 at a dose of 10 mg/kg (p.o.) suppressed the passive anaphylactic bronchoconstriction in guinea pigs.
- 社団法人日本農芸化学会の論文
- 1988-12-23
著者
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Ohmori Kenji
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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KASE Hiroshi
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Ohmori Kenji
Pharmaceutical Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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Kase Hiroshi
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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KITAMURA Shigeto
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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HASHIZUME Kazuo
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Hashizume Kazuo
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Kitamura S
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Kitamura Shigeto
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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