Involvement of Neuropeptides in the Allergic Nasal Obstruction in Guinea Pigs
スポンサーリンク
概要
- 論文の詳細を見る
The purposes of the present study were i) to determine whether neuropeptides induce the nasal obstruction in guinea pigs, and ii) to examine the possible involvement of neuropeptides in allergic nasal obstruction. The decrease in nasal cavity volume was determined by acoustic rhinometry as an index of nasal obstruction. In non-sensitized guinea pigs, substance P (SP), neurokinin A (NKA) and calcitonin gene-related peptide (CGRP) caused the nasal obstruction 10 to 30 min after their intranasal application. LY303870 (1 mg/kg), a tachykinin NK1-receptor antagonist; SR48968 (1 mg/kg), a tackykinin NK2-receptor antagonist; and CGRP(8 - 37) (50 nmol/kg), a CGRP1-receptor antagonist, administered intravenously before the intranasal application of the neuropeptides, inhibited the responses induced by SP, NKA and CGRP, respectively. In the guinea pigs sensitized with dinitrophenyl-coupled Ascaris suum allergenic extract, the intranasal antigen challenge caused nasal obstruction. The response was biphasic and consisted of the early phase response (EPR) and the late phase response (LPR), which developed 30 min and 6 h, respectively, after the antigen challenge. Intravenous administration of LY303870 (1 mg/kg) before the antigen challenge inhibited the EPR, while those of SR48968 (1 mg/kg) and CGRP(8 - 37) (50 nmol/kg) inhibited the LPR. The present results suggest that neuropeptides are involved in the allergic nasal obstruction.
- 社団法人 日本薬理学会の論文
- 2001-06-01
著者
-
OHMORI Kenji
Department of Crystalline Materials Science, Graduate School of Engineering, Nagoya University
-
Ohmori K
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
-
石井 昭男
協和発酵医薬研
-
KARASAWA Akira
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
-
ISHII Akio
Toxicological Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
-
Ohmori Kenji
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
-
Ohmori Kenji
Department Of Crystalline Materials Science Graduate School Of Engineering Nagoya University
-
Karasawa Akira
協和醗酵工業
-
Karasawa A
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Kogyo Co. Ltd.
-
Karasawa Akira
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
-
Karasawa Akira
Laboratory Of Plant Pathology Department Of Applied Life Science Graduate School Of Agricultural Sci
-
Karasawa Akira
Department Of Bioscience Faculty Of Science And Technology Kwansei Gakuin University
-
KAISE Toshihiko
Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
-
KAISE Toshihiko
Department of Pharmacology, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co, Ltd
-
AKAMATSU Yukino
Department of Pharmacology, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co, Ltd
-
ISHII Akio
Department of Pharmacology, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co, Ltd
-
IKEMURA Toshihide
Department of Pharmacology, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
-
Kaise Toshihiko
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
-
ISHII AKIO
Pharmaceuticals Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
-
Ohmori K
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd
-
Ishii A
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Kogyo Co. Ltd.
-
Karasawa Akira
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
-
Karasawa Akira
Deparment Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
-
Akamatsu Yukino
Department Of Pharmacology Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
-
Ikemura T
Department Of Pharmacology Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
-
Ishii Akio
Department Of Mechanical Science And Bioengineering Graduate School Of Engineering Science Osaka University
-
石井 昭男
協和発酵工業(株)医薬研究所
-
ISHII Akio
Toxicological Research Laboratories Kyowa Hakko Kogyo Co., Ltd.
関連論文
- Growth Processes and Electrical Characteristics of Silicon Nitride Films Formed on Si(100) by Radical Nitrogen
- 137 Poly-L-arginine誘発ラット皮膚血管透過性亢進および掻き行動に対する塩酸オロパタジンの抑制作用
- New Approach for Measurement of Sympathetic Nervous Abnormality in Conscious, Spontaneously Hypertensive Rats
- Excitation and Inhibition via Adenosine Receptors of the Twitch Response to Electrical Stimulation in Isolated Guinea Pig Ileum
- Ecarazine Hydrochloride, Hydralazineおよび代謝物のPhosphodiesterase阻害活性について
- Studies on Ecarazine Hydrochloride (Apiracohl). II. Spectrofluorometric Determination of Ecarazine Hydrochloride and Its Metabolite in Plasma
- ^C標識N_1-Carboethoxy-N_2-hydrazinophthalazine Hydrochloride(Apiracohl[○!R])の研究(第1報)標識化合物の合成と代謝
- 新抗てんかん薬Sodium Dipropylacetateの研究 代謝物と代謝過程の検討
- Investigation of nephrotoxicity induced by Cisplatin in common marmosets.
- Effects of anticancer drugs (MMC and ACNU) on hematology and blood biochemistry of common marmosets.
- Acceleration by KW-5092 of Intestinal Motility Associated With Acetylcholine Release In Vivo
- REVIEW : New Drug and Recent Technique : Pharmacological, Pharmacokinetic and Clinical Properties of Olopatadine Hydrochloride, a New Antiallergic Drug
- Effects of olopatadine hydrochloride on the release of thromboxane B_2 and histamine from nasal mucosa after antigen-antibody reaction in guinea pigs
- Effects of Olopatadine Hydrochloride on the Cutaneous Vascular Hyperpermeability and the Scratching Behavior Induced by Poly-_L-Arginine in Rats
- Inhibitory Effect of Olopatadine Hydrochloride on the Sneezing Response Induced by Intranasal Capsaicin Challenge in Guinea Pigs
- Involvement of Neuropeptides in the Allergic Nasal Obstruction in Guinea Pigs
- Inhibitory effect of olopatadine hydrochloride (KW-4679), a novel antiallergic drug, on peptide leukotriene release from human eosinophils
- Possible Involvement of 5-HT_4 Receptors, in Addition to 5-HT_3 Receptors, in the Emesis Induced by High-Dose Cisplatin in Suncus murinus
- The Effect of Zaldaride Maleate, an Antidiarrheal Compound, on Acetylcholine-Induced Intestinal Electrolyte Secretion
- Effect of Zaldaride Maleate, an Antidiarrheal Compound, on 16, 16-Dimethyl Prostaglandin E_2-Induced Intestinal Ion Secretion in Rats
- Effects of Zaldaride Maleate, an Antidiarrheal Compound, on Intracellular Ca^-Mediated Short-Circuit Current Response in the Rat Colonic Mucosa
- Effect of Oxatomide on Experimental Allergic Rhinitis in Guinea Pigs
- 498 マウスのアレレギー性鼻炎モデルにおける鼻粘膜からの肥満細胞遊走因子の産生
- A New Series of Antiallergic Agents. II. Synthesis and Activity of New 6,11-Dihydrodibenz[b, e]oxepin-carboxylic Acid Derivatives
- A New Series of Antiallergic Agents. I. Synthesis and Activity of 11-(2-Aminoethyl)thio-6,11-dihydrodibenz[b, e]oxepin Derivatives
- Comparison of the Antidiarrheal Effects of Zaldaride Maleate and Its Optical Isomers in Rats
- Gender Differences in the Antidiarrheal Effect of Zaldaride Maleate in Rats
- Antidiarrheal Effects of Zaldaride Maleate After Oral, Intravenous and Subcutaneous Administration to Rats
- Adenosine Uptake Inhibition Ameliorates Cerulein-Induced Acute Pancreatitis in Mice
- EFFECTS OF N-(4-METHYLBENZYLTHIOCARBONYL)-L-PHENYLALANINE (KF 1492), A NEW HYPOLIPIDEMIC DRUG, AND CLOFIBRATE ON LIPIDS METABOLISM
- EFFECTS OF N-(4-METHYLBENZYLTHIOCARBONYL)-L-PHENYL-ALANINE (KF 1492), A NEW PHENYLALANINE DERIVATIVE, ON LIPID SYNTHESIS IN VIVO INHIBITION OF HEPATIC CHOLESTEROL SYNTHESIS AND 3-HYDROXY-3-METHYLGLUTARYL-CO A REDUCTASE
- Binding of Aminoglycoside Antibiotics to Acidic Mucopolysaccharides
- INHIBITORY EFFECTS OF REPEATED INTRAVENOUS INJECTIONS OF DEXAMETHASONE ON PULMONARY TOXICITY OF A NEW MITOMYCIN C ANALOGUE, KW-2149, IN A NOVEL RAT MODEL
- Inhibitory effects of dexamethasone on pulmonary toxicity of a new mitomycin C analogue KW-2149 in a novel rat model.
- 21D-03-5 Effects of Restricted Water Intake and the Administration of Furosemide, BSO and BHA on Pulmonary Toxicity of KW-2149 (Mitomycin C Analog).
- Synergistic Effect of Naphtoquinones on the Mutagenicity of Nitroarene
- Effect of KW-4679, an Orally Active Anti-allergic Drug, on Antigen-Induced Airway Hyperresponsiveness in Actively Sensitized Guinea Pigs
- Growth Processes and Electrical Characteristics of Silicon Nitride Films Formed on Si(100) by Radical Nitrogen
- Microscopic Observation of X-Ray Irradiation Damages in Ultra-Thin SiO_2 Films
- Oxide Formation on Si(100)-2×1 Surfaces Studied by Scanning Tunneling Microscopy/Scanning Tunneling Spectroscopy
- Study on Oxidation of Si(100)-2x1 Surfaces by Scanning Tunneling Microscopy/Scanning Tunneling Spectroscopy
- EXPRESSION OF THE XENOPUS HOMOLOGUES OF HUMAN UBIQUITIN-CONJUGATING ENZYME E2 IN THE OOCYTE MATURSATION PROCESS OF XENOPUS(Developmental Biology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Inhibitory Effect of KW-4679, an Anti-allergic Drug, on Tachykinin-Mediated Airway Response Induced by Electric Vagal Stimulation in Guinea Pigs
- The Effect of KW - 4679, and Antiallergic Drug, on Experimental Allergic Rhinitis in Guinea Pigs: Effects on Nasal Blockage
- Biochemical and Pharmacological Properties of 5-Lipoxygenase Inhibitor KF8940(Biological Chemistry)
- Rhein, an Active Metabolite of Diacerein, Suppresses the Interleukin-1α-Induced Proteoglycan Degradation in Cultured Rabbit Articular Chondrocytes
- Insecticidal activity of oxadiazine insecticide indoxacarb and its N-decarbomethoxylated metabolite and their modulations of voltage-gated sodium channels
- Effects of Olopatadine Hydrochloride on the Increase of Histamine and Peptide-Leukotrienes Concentrations in Nasal Lavage Fluid Following the Antigen-Antibody Reaction in Actively Sensitized Guinea Pigs
- A Variant of Cucumber mosaic virus Is Restricted to Local Lesions in Inoculated Tobacco Leaves with a Hypersensitive Response
- Isolation of Molecular Markers Linked to the Cry Locus Conferring Resistance to Cucumber mosaic cucumovirus Infection in Cowpea
- Effects of KW-5617 (Zaldaride Maleate), a Potent and Selective Calmodulin Inhibitor, on Secretory Diarrhea and on Gastrointestinal Propulsion in Rats
- Effect of KW-5092, Novel Gastroprokinetic Agent, on the Peristalsis in the Isolated Guinea Pig Ileum
- Effects of KW-3902 (8-(Noradamantan-3-yl)-1,3-dipropylxanthine), an Adenosine A_1-Receptor Antagonist, on Urinary Excretions of Various Electrolytes in Rats
- Antihypertinsive Effects of KW - 3902, an Adenosine A_1 - Receptor Antagonist, in Dahl Salt-Sensitive Rats
- Effects of KW-3902, an Adenosine A_1 - Receptor Antagonist, on Ascites Volume in Puromycin Aminonucleoside (PAN) - Induced Nephrotic Rats
- Effects of the Adenosine A_1 - Receptor Antagonist on Defecation, Small Intestinal Propulsion and Gastric Emptying in Rats
- Protective Effects of KW-3902, an Adenosine A_1-Receptor Antagonist, against Cisplatin-Induced Acute Renal Failure in Rats
- Effects of Alendronate and Prednisolone on a Model of Rheumatoid Arthritis in Mice
- EFFECTS OF ECARAZINE, PRAZOSIN, PHENTOLAMINE AND HEXAMETHONIUM ON THE VASOPRESSOR REFLEXES INDUCED BY BILATERAL CAROTID ARTERY OCCLUSION AND HEAD-UP TILTING IN CATS
- PROTECTIVE EFFECT OF FLUNARIZINE AGAINST CEREBRAL HYPOXIA-ANOXIA IN MICE AND RATS
- Protective Effects of Benidipine Hydrochloride (KW-3049), a Calcium Antagonist, against Experimental Arterial Calcinosis and Endothelial Dysfunction in Rats
- Early Thrombolysis by Recombinant Tissue-Plasminogen Activator Is Beneficial to the Ischemic Myocardium
- Inhibitory Effect of KW-3049,A New 1,4-Dihydropyridine Calcium Antagonist, on the Reduction of Myocardial Creatine Kinase Activity and High-Energy Phosphate Content in Rats Subjected to Coronary Artery Ligation
- Synthesis of Tricyclic Compounds as Steroid 5α-Reductase Inhibitors
- Glybuzole(2-Benzenesulfonamido-5-tert-butyl-1-thia-3,4-diazole)のフエノバルビタール, SKF 525Aおよび四塩化炭素前処理ラットにおける代謝
- EFFECTS OF NONSPECIFIC SMOOTH MUSCLE RELAXANTS ON GLYCOGEN PHOSPHORYLASE ACTIVITY IN DEPOLARIZED TAENIA CAECUM OF GUINEA PIG
- EFFECTS OF NONSPECIFIC SMOOTH MUSCLE RELAXANTS ON TISSUE CONCENTRATIONS OF HIGH ENERGY PHOSPHATES AND MECHANICAL ACTIVITY OF NORMAL POLARIZED AND DEPOLARIZED INTESTINAL SMOOTH MUSCLES FROM GUINEA PIG
- Antithrombotic Effects of KW-3635, a Thromboxane A2-Receptor Antagonist, in Guinea Pigs
- Protective Effect of Benidipine against the Development of Glomerular Sclerosis in Experimental Nephrotic Syndrome
- Protective Effects of Benidipine on Arachidonic Acid-Induced Acute Cerebral Ischemia in Rats
- Changes in Nasal Cavity Volume and Target Area of Exposure to Nasal Drops with Age in Rats
- BUTANOL EXTRACTS FROM MYELIN FRAGMENTS-V. 5-HYDROXYTRYPTAMINE BINDING TO THE MITOCHONDRIAL BUTANOL EXTRACTS AND THE INTER-RELATIONSHIP WITH MYELIN BUTANOL EXTRACTS
- EFFECTS OF PRAZOSIN, PHENTOLAMINE, AND YOHIMBINE ON THE PRESSOR RESPONSES INDUCED BY NORADRENALINE, PHENYLEPHRINE, AND BILATERAL CAROTID ARTERY OCCLUSION IN ANAESTHETIZED DOGS
- KW-1062標識体の吸収,分布,排泄 (KW-1062論文特集号)
- Stimulating Effects of KW-5092, a Novel Gastroprokinetic Agent, on the Gastric Emptying, Small Intestinal Propulsion and Colonic Propulsion in Rats
- KW - 5092, a Novel Gastroprokinetic Agent, Reverses the Norepinephrine - Induced Decline of the Gastric Mucosal Blood Flow in Rats
- EFFECT OF STIMULATION OF LOCUS COERULEUS ON THE EVOKED POTENTIAL IN THE AMYGDALA IN RATS
- EFFECT OF SODIUM DIPROPYLACETATE ON CONFLICT BEHAVIOR IN RATS
- EFFECT OF L-5HTP ON TREMORINE- OR OXOTREMORINE- INDUCED TREMOR IN MICE AND RATS
- Protective Effect of KW-3635, a Specific Thromboxane A2-Receptor Antagonist, on Experimental Glomerulonephritis in Mice
- Interaction of 5-hydroxytryptamine and ketanserin in rat vas deferens subjected to low frequency field stimulation.
- 拘束水浸ストレスおよびアスピリンによるラット胃粘液の変動に対するKW-5805の作用
- 新規ベンジルピリジン誘導体KW-6055の中枢コリン作動性神経系に及ぼす影響
- 5-〔2-(Diethylamino)ethyl〕amino-5,11-dihydro〔1〕benzoxepino〔3,4-b〕pyridine trihydrochloride(KW-5805)の胃粘液生成に対する作用
- Inhibitory Effects of KW-3902, a Selective Adenosine A1-Receptor Antagonist, on the Adenosine-Induced Shortening of Action Potential Duration in Guinea Pig Atrial Muscles.
- Protective Effects of KW-3902, an Adenosine A1-Receptor Antagonist, Against the Nephropathy Induced by Repeated Administration of Cisplatin in Rats.
- Protection by benidipine hydrochloride (KW-3049), a calcium antagonist, of ischemic kidney in rats via inhibitions of Ca-overload, ATP-decline and lipid peroxidation.
- Susceptibility to Adenosine Agonists of Giant Migrating Contractions Induced by Glycerol Enema in Anesthetized Rats.
- Effects of KW-3635, a Specific Thromboxane A2-Receptor Antagonist, on the Development of Lupus Nephritis in NZB*NZW F1 Mice.
- Enhancement by KW-5092, a Novel Gastroprokinetic Agent, of the Release of Acetylcholine from Enteric Neurons in the Guinea Pig Ileum.
- Protective Effect of Cisapride against Indomethacin-Induced Obstruction of the Gastric Mucosal Hemodynamics in Rats.
- Effects of KW-3902, a Novel Adenosine A1-Receptor Antagonist, on Cephaloridine-Induced Acute Renal Failure in Rats.
- Protective Effects of KW-3635, a Thromboxane A2 Antagonist, on Arachidonic Acid-Induced Transient Cerebral Ischemia in Dogs.
- Enhancement by KW-5092, a Novel Gastroprokinetic Agent, of the Gastrointestinal Motor Activity in Dogs.
- Diuretic Effects of KW-3902, a Novel Adenosine A1-Receptor Antagonist, in Various Models of Acute Renal Failure in Rats.
- Pharmacological Properties of KF18259, a Novel 5-HT3-Receptor Antagonist, in Rats: Inhibition of the Distal Colonic Function.
- Effects of KW-5092, a Novel Gastroprokinetic Agent, on the Delayed Colonic Propulsion in Rats.
- Colonic Giant Migrating Contractions Induced by Glycerol Enema in Anesthetized Rats.
- Effects of Benidipine on Renal Function in Anesthetized Spontaneously Hypertensive Rats.
- Protective Effects of KW-3902, an Adenosine A1-Receptor Antagonist, Against Cisplatin-Induced Apoptosis in Rat Kidney.