Protective Effect of KW-3635, a Specific Thromboxane A<SUB>2</SUB>-Receptor Antagonist, on Experimental Glomerulonephritis in Mice
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概要
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We studied the effect of KW-3635, a selective thromboxane A<SUB>2</SUB> (TXA<SUB>2</SUB>)-receptor antagonist, on experimental glomerulonephritis. The glomerulonephritis was induced in mice by the administration of rabbit anti-mouse glomerular basement membrane (GBM) antibody. It was characterized as proteinuria, changes of serum biochemical parameters and glomerular histopathological abnormalities. The administration of KW-3635 (30 mg/kg/day, p.o.) significantly ameliorated the proteinuria, elevation of serum urea nitrogen and the thickening of GBM. These data suggest that TXA<SUB>2</SUB> may play an important pathogenic role in the development and progression of glomerulonephritis.
著者
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Karasawa Akira
Deparment Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Sato Kiyoshi
Department Of Biological And Chemical Engineering Gunma University
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Kawakage Michiyo
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Sato Kiyoshi
Department of Toxicology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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