Protective Effects of Benidipine Hydrochloride (KW-3049), a Calcium Antagonist, against Experimental Arterial Calcinosis and Endothelial Dysfunction in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Protective effects of benidipine hydrochloride (KW-3049) against arterial calcinosis and its possible mechanisms of action have been investigated. Arterial calcinosis was induced in rats by combined administration of vitamin D_2 (1050000 IU/kg, s.c.) and nicotine (12.5 mg/kg, p.o., b.i.d.) for 6 successive days. Calcium antagonists, benidipine or nifedipine, were given orally twice a day during the same period. The aortic calcium content in vitamin D_2 and nicotine-treated (control) rats increased to about 25 times that in normal rats, accompanying an increase of serum calcium level. Benidipine (10 mg/kg, p.o., b.i.d.) reduced the aortic calcium content to about 18% of control rats without reducing the serum calcium level. Although the presence of aortic endothelial cells was observed under light microscopy in control rats, their surfaces were degenerated under scanning electron microscopy. Benidipine exerted a protective effect against these degenerative changes. Acetylcholine-induced endothelial dependent relaxation was attenuated in control rats, compared with that in normal rats. Benidipine significantly improved this attenuation of the relaxation. These results suggest that the anticalcinotic effect of benidipine is accompanied by its protective effect on endothelial cells.
- 公益社団法人日本薬学会の論文
著者
-
KARASAWA Akira
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
-
Karasawa Akira
協和醗酵工業
-
Karasawa A
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Kogyo Co. Ltd.
-
Karasawa Akira
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
-
Karasawa Akira
Laboratory Of Plant Pathology Department Of Applied Life Science Graduate School Of Agricultural Sci
-
Karasawa Akira
Department Of Bioscience Faculty Of Science And Technology Kwansei Gakuin University
-
Kubo K
Department Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
-
Kubo Kazuhiro
Pharmaceutical Research Laboratories Of Kyowa Hakko Kogyo Co. Ltd.
-
Kubo Kazuhiro
Department Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
-
HIGO Katsuya
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
-
Higo K
Kyowa Hakko Kogyo Co. Ltd. Shizuoka Jpn
-
Karasawa Akira
Deparment Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
-
KUBO Kazuhiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
-
KUBO Kazuhiro
Department of Cardiovascular Pharmacology, Pharmaceuticals Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
関連論文
- Excitation and Inhibition via Adenosine Receptors of the Twitch Response to Electrical Stimulation in Isolated Guinea Pig Ileum
- Effects of olopatadine hydrochloride on the release of thromboxane B_2 and histamine from nasal mucosa after antigen-antibody reaction in guinea pigs
- Effects of Olopatadine Hydrochloride on the Cutaneous Vascular Hyperpermeability and the Scratching Behavior Induced by Poly-_L-Arginine in Rats
- Inhibitory Effect of Olopatadine Hydrochloride on the Sneezing Response Induced by Intranasal Capsaicin Challenge in Guinea Pigs
- Involvement of Neuropeptides in the Allergic Nasal Obstruction in Guinea Pigs
- Inhibitory effect of olopatadine hydrochloride (KW-4679), a novel antiallergic drug, on peptide leukotriene release from human eosinophils
- Possible Involvement of 5-HT_4 Receptors, in Addition to 5-HT_3 Receptors, in the Emesis Induced by High-Dose Cisplatin in Suncus murinus
- The Effect of Zaldaride Maleate, an Antidiarrheal Compound, on Acetylcholine-Induced Intestinal Electrolyte Secretion
- Effect of Zaldaride Maleate, an Antidiarrheal Compound, on 16, 16-Dimethyl Prostaglandin E_2-Induced Intestinal Ion Secretion in Rats
- Effects of Zaldaride Maleate, an Antidiarrheal Compound, on Intracellular Ca^-Mediated Short-Circuit Current Response in the Rat Colonic Mucosa
- Adenosine Uptake Inhibition Ameliorates Cerulein-Induced Acute Pancreatitis in Mice
- Effects of KF-14363 on Liver Fibrosis in Rats with Chronic Liver Injury Induced by Carbon Tetrachloride
- EXPRESSION OF THE XENOPUS HOMOLOGUES OF HUMAN UBIQUITIN-CONJUGATING ENZYME E2 IN THE OOCYTE MATURSATION PROCESS OF XENOPUS(Developmental Biology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Effects of 1-[(2-Thiazolin-2-yl) amino] acetyl-4-(1,3-dithiol 2-ylidene)-2,3,4,5-tetrahydro-1H-1-benzazepin-3,5-dione Hydrochloride (KF-14363) on Liver Regeneration and Function of Hepatic Mitochondria in Partially Hepatectomized Rats
- Insecticidal activity of oxadiazine insecticide indoxacarb and its N-decarbomethoxylated metabolite and their modulations of voltage-gated sodium channels
- Effects of Olopatadine Hydrochloride on the Increase of Histamine and Peptide-Leukotrienes Concentrations in Nasal Lavage Fluid Following the Antigen-Antibody Reaction in Actively Sensitized Guinea Pigs
- A Variant of Cucumber mosaic virus Is Restricted to Local Lesions in Inoculated Tobacco Leaves with a Hypersensitive Response
- Isolation of Molecular Markers Linked to the Cry Locus Conferring Resistance to Cucumber mosaic cucumovirus Infection in Cowpea
- Effects of KW-5617 (Zaldaride Maleate), a Potent and Selective Calmodulin Inhibitor, on Secretory Diarrhea and on Gastrointestinal Propulsion in Rats
- Effect of KW-5092, Novel Gastroprokinetic Agent, on the Peristalsis in the Isolated Guinea Pig Ileum
- Effects of KW-3902 (8-(Noradamantan-3-yl)-1,3-dipropylxanthine), an Adenosine A_1-Receptor Antagonist, on Urinary Excretions of Various Electrolytes in Rats
- Antihypertinsive Effects of KW - 3902, an Adenosine A_1 - Receptor Antagonist, in Dahl Salt-Sensitive Rats
- Effects of KW-3902, an Adenosine A_1 - Receptor Antagonist, on Ascites Volume in Puromycin Aminonucleoside (PAN) - Induced Nephrotic Rats
- Effects of the Adenosine A_1 - Receptor Antagonist on Defecation, Small Intestinal Propulsion and Gastric Emptying in Rats
- Protective Effects of KW-3902, an Adenosine A_1-Receptor Antagonist, against Cisplatin-Induced Acute Renal Failure in Rats
- EFFECTS OF ECARAZINE, PRAZOSIN, PHENTOLAMINE AND HEXAMETHONIUM ON THE VASOPRESSOR REFLEXES INDUCED BY BILATERAL CAROTID ARTERY OCCLUSION AND HEAD-UP TILTING IN CATS
- PROTECTIVE EFFECT OF FLUNARIZINE AGAINST CEREBRAL HYPOXIA-ANOXIA IN MICE AND RATS
- Protective Effects of Benidipine Hydrochloride (KW-3049), a Calcium Antagonist, against Experimental Arterial Calcinosis and Endothelial Dysfunction in Rats
- Early Thrombolysis by Recombinant Tissue-Plasminogen Activator Is Beneficial to the Ischemic Myocardium
- Inhibitory Effect of KW-3049,A New 1,4-Dihydropyridine Calcium Antagonist, on the Reduction of Myocardial Creatine Kinase Activity and High-Energy Phosphate Content in Rats Subjected to Coronary Artery Ligation
- PURIFICATION OF HISTAMINE RECEPTOR (V) —ASSESSMENT OF THE DOUBLE LABELING METHOD—
- EFFECTS OF NONSPECIFIC SMOOTH MUSCLE RELAXANTS ON GLYCOGEN PHOSPHORYLASE ACTIVITY IN DEPOLARIZED TAENIA CAECUM OF GUINEA PIG
- EFFECTS OF NONSPECIFIC SMOOTH MUSCLE RELAXANTS ON TISSUE CONCENTRATIONS OF HIGH ENERGY PHOSPHATES AND MECHANICAL ACTIVITY OF NORMAL POLARIZED AND DEPOLARIZED INTESTINAL SMOOTH MUSCLES FROM GUINEA PIG
- Antithrombotic Effects of KW-3635, a Thromboxane A2-Receptor Antagonist, in Guinea Pigs
- Protective Effect of Benidipine against the Development of Glomerular Sclerosis in Experimental Nephrotic Syndrome
- Protective Effects of Benidipine on Arachidonic Acid-Induced Acute Cerebral Ischemia in Rats
- BUTANOL EXTRACTS FROM MYELIN FRAGMENTS-V. 5-HYDROXYTRYPTAMINE BINDING TO THE MITOCHONDRIAL BUTANOL EXTRACTS AND THE INTER-RELATIONSHIP WITH MYELIN BUTANOL EXTRACTS
- Stimulating Effects of KW-5092, a Novel Gastroprokinetic Agent, on the Gastric Emptying, Small Intestinal Propulsion and Colonic Propulsion in Rats
- KW - 5092, a Novel Gastroprokinetic Agent, Reverses the Norepinephrine - Induced Decline of the Gastric Mucosal Blood Flow in Rats
- Protective Effect of KW-3635, a Specific Thromboxane A2-Receptor Antagonist, on Experimental Glomerulonephritis in Mice
- Interaction of 5-hydroxytryptamine and ketanserin in rat vas deferens subjected to low frequency field stimulation.
- Inhibitory Effects of KW-3902, a Selective Adenosine A1-Receptor Antagonist, on the Adenosine-Induced Shortening of Action Potential Duration in Guinea Pig Atrial Muscles.
- Protective Effects of KW-3902, an Adenosine A1-Receptor Antagonist, Against the Nephropathy Induced by Repeated Administration of Cisplatin in Rats.
- Enhancement by KW-5092, a Novel Gastroprokinetic Agent, of the Release of Acetylcholine from Enteric Neurons in the Guinea Pig Ileum.
- Protective Effect of Cisapride against Indomethacin-Induced Obstruction of the Gastric Mucosal Hemodynamics in Rats.
- Effects of KW-3902, a Novel Adenosine A1-Receptor Antagonist, on Cephaloridine-Induced Acute Renal Failure in Rats.
- Inhibition of thromboxane A2-induced vasocontraction by KF4939, a new anti-platelet agent, in rabbit mesenteric and dog coronary arteries.
- Protective Effects of KW-3635, a Thromboxane A2 Antagonist, on Arachidonic Acid-Induced Transient Cerebral Ischemia in Dogs.
- Enhancement by KW-5092, a Novel Gastroprokinetic Agent, of the Gastrointestinal Motor Activity in Dogs.
- Diuretic Effects of KW-3902, a Novel Adenosine A1-Receptor Antagonist, in Various Models of Acute Renal Failure in Rats.
- Pharmacological Properties of KF18259, a Novel 5-HT3-Receptor Antagonist, in Rats: Inhibition of the Distal Colonic Function.
- Effects of KW-5092, a Novel Gastroprokinetic Agent, on the Delayed Colonic Propulsion in Rats.
- Colonic Giant Migrating Contractions Induced by Glycerol Enema in Anesthetized Rats.
- Effects of Benidipine on Renal Function in Anesthetized Spontaneously Hypertensive Rats.
- Protective Effects of KW-3902, an Adenosine A1-Receptor Antagonist, Against Cisplatin-Induced Apoptosis in Rat Kidney.
- Effects of Repeated Administration of KW-3902, a Novel Adenosine A1-Receptor Antagonist, on Its Pharmacological Actions.
- Protective Effects of KW-3902, a Novel Adenosine Al-Receptor Antagonist, against Gentamicin-Induced Acute Renal Failure in Rats.
- Inhibitory Effect of KW-3635, a New Thromboxane A2-Receptor Antagonist, on Arterial Thrombosis in Guinea Pigs.
- Renal tubular site of action of KW-3902, a novel adenosine A1-receptor antagonist, in anesthetized rats.